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Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis
Earlier and larger use of MAMP was associated with increased risk of psychosis, compatible with the view that pre-morbid schizoid/schizotypal personality predisposes MAMP users to develop psychosis, and that the greater the personality vulnerability, the longer the psychosis will persist. Expand
MicroRNA expression signature of human sarcomas
Different histological types of sarcoma have distinct miRNA expression patterns, reflecting the apparent lineage and differentiation status of the tumors, and the identification of unique miRNA signatures in each tumor type may indicate their role in tumorigenesis and may aid in diagnosis of soft tissue sarcomas. Expand
Cloning and Characterization of Mouse RIP140, a Corepressor for Nuclear Orphan Receptor TR2
It was demonstrated that in the presence of RIP140, a cytosolic, green fluorescent protein-tagged TR2 LBD translocated into the nucleus, and TR2 and RIP140 were coimmunoprecipitated from the cell extract, indicating that the interaction between RIP140 and the LBD of TR2 occurred in vivo. Expand
Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells.
Investigation of the role of phosphatidylinositol 3-kinase-Akt and mitogen-activated protein (MAP) kinase signaling pathways in the induction of rGSTA2 by tert-butylhydroquinone demonstrated that t-BHQ activated PI3-kinases and Akt, which was responsible for ARE-mediated rG STA2 induction, and that ERK might negatively regulate rGstA2 expression. Expand
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In
  • M. Jarvis, H. Yu, +6 authors E. Kowaluk
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental…
  • 1 December 2000
ABT-702 is a novel and potent non-nucleoside AK inhibitor that effectively reduces acute thermal nociception in the mouse by a nonopioid, non-nonsteroidal anti-inflammatory drug, ADO A(1) receptor-mediated mechanism. Expand
Pharmacological characterization of RS 25259‐197, a novel and selective 5‐HT3 receptor antagonist, in vivo
RS 25259‐197 is a novel, highly potent and orally active 5‐HT3 receptor antagonist in vivo and appears to be a significant improvement over ondansetron in terms of potency and duration of action. Expand
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In
ABT-702 is a novel,non-nucleoside AK inhibitor, with a nonopioid, non-nonsteroidal anti-inflammatory drug mechanism of action, which shows antinociceptive and anti- inflammatory activity in vivo. Expand
Loss of the polycomb protein Mel-18 enhances the epithelial–mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer
Mel-18 functions as a tumor suppressor by its novel negative control of the EMT, achieved through regulating the expression of miR-205 and its target genes, ZEB1 and ZEB2. Expand
Thrombospondin‐1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia
Objective To evaluate the expression of thrombospondin‐1 (TSP‐1, a potent inhibitor of angiogenesis) and vascular endothelial growth factor (VEGF, an important angiogenic factor in solid tumours) inExpand
Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes
It was demonstrated that expression of this protein dramatically repressed both the basal and the retinoic acid (RA)‐regulated promoter activities of this reporter system, suggesting this orphan receptor could play a role in modulating both the basic transcription machinery and the RA signaling pathway during embryogenesis and male germ‐cell differentiation. Expand