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Intracellular Targeting Mechanisms by Antimicrobial Peptides
This review focuses on the major intracellular targeting activities reported in AMPs, which include nucleic acids and protein biosynthesis and protein-folding, protease, cell division, cell wall biosynthesis, and lipopolysaccharide inhibition.
The Potential of Antiviral Peptides as COVID-19 Therapeutics
- Aravindh Mahendran, Yin Sze Lim, Chee-Mun Fang, H. Loh, C. Le
- Biology, MedicineFrontiers in Pharmacology
- 15 September 2020
Interestingly, there are AVPs demonstrated to exert prophylactic and therapeutic effects against coronaviruses (CoVs) and it is suggested that further development of this class of compounds in the face of the current pandemic threat is warranted.
Activity of Novel Synthetic Peptides against Candida albicans
Peptides demonstrated low haemolytic activity but significant toxicity on two normal human epithelial cell lines and showed synergistic effects when used in combination with conventional antifungals when the therapeutic application of the peptides is limited.
Phytosterols isolated from Clinacanthus nutans induce immunosuppressive activity in murine cells
Sustainable utilization of biowaste compost for renewable energy and soil amendments.
Extraction of protein from food waste: An overview of current status and opportunities.
- H. Kamal, C. Le, A. Salter, Asgar Ali
- MedicineComprehensive reviews in food science and food…
- 5 April 2021
The current analysis reveals the extraction of protein from FW is a many-sided (complex) issue, and that identifies for a stronger and extensive integration of diverse extraction perspectives, focusing on nutritional quality, yield, and functionality of the isolated protein as a valued recycled ingredient.
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae
The results suggest that the hybrid peptides designed based on two natural peptides based on indolicidin and ranalexin could be suitable candidates for antibacterial drug development.
Capsular Serotype and Antibiotic Resistance of Streptococcus pneumoniae Isolates in Malaysia
A number of serotypes, especially those associated with high penicillin resistance, have been formulated in the PCV7, therefore, the protections expected from the routine use ofPCV7 would be encouraging for the Malaysian populations.
The epidemiology of pneumococcal carriage and infections in Malaysia
- C. Le, J. Jefferies, M. Yusof, S. Sekaran, S. Clarke
- Medicine, BiologyExpert review of anti-infective therapy
- 1 June 2012
Major aspects discussed include pneumococcal carriage, disease incidence and prevalence, age factors, invasiveness of pneumococci, serotypes, molecular epidemiology and antibiotic susceptibility.