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Determination of oxeladin in human plasma by gas chromatography--mass spectrometry.
TLDR
A capillary gas chromatographic method with mass-selective detection was developed for the determination of oxeladin in human plasma and demonstrated to be sensitive, accurate and precise enough to support pharmacokinetic evaluation of the drug at doses down to 30 mg.
Kinetics of allopurinol and its metabolite oxypurinol after oral administration of allopurinol alone or associated with benzbromarone in man. Simultaneous assay of hypoxanthine and xanthine by gas
TLDR
The action of the two agents may be synergistic and not antagonistic, a pharmacological justification for the therapeutic use of this drug association and its role on the blood uric acid lowering action is complex.
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