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Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis
Results provide qualified support for the critical period hypothesis and could be extended to include the prodrome as well as early psychosis, and duration of untreated illness has any independent effect on outcome. Expand
Schizophrenia and the city: A review of literature and prospective study of psychosis and urbanicity in Ireland
Results of a prospective study of urbanicity and schizophrenia in Ireland are presented, which provides persuasive evidence that risk for schizophrenia increases with urban birth and/or upbringing, especially among males. Expand
Determinants of quality of life at first presentation with schizophrenia.
Reducing the duration of untreated psychosis may have a beneficial effect on the subsequent QOL of patients presenting with schizophrenia, and may warrant specific treatment interventions to prevent the development of secondary handicaps. Expand
Diagnostic specificity and predictors of neurological soft signs in schizophrenia, bipolar disorder and other psychoses over the first 4 years of illness
Schizophrenia and bipolar disorder are indistinguishable in terms of neurodysfunction at presentation, but at 4 years NSS closely parallel psychopathology and mixed-handedness indicating that NSS may be a function of these factors or possibly an independent factor operates equally upon both symptoms and neurological function. Expand
Quality of life in schizophrenia: relationship to sociodemographic factors, symptomatology and tardive dyskinesia
The influence of sociodemographic, clinical and treatment factors on the quality of life of patients with schizophrenia has yet to be fully defined. We evaluated the quality of life of patients withExpand
The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins.
These findings constitute direct evidence for disturbed craniofacial development in schizophrenia and indicate origins in the foetal period during which the characteristic human facial pattern evolves in close association with brain differentiation. Expand
Early insight predicts depression and attempted suicide after 4 years in first‐episode schizophrenia and schizophreniform disorder
Objective:  To map the development of insight in the 4 years after presentation with first‐episode schizophrenia and schizophreniform disorder and to determine the effects of evolving insight onExpand
A prospective evaluation of adherence to medication in first episode schizophrenia
While high positive symptom scores pre-date and predict non-adherence in most patients, reduced insight is the best predictor of non- adherence in patients who do not misuse alcohol or other drugs. Expand
Untreated illness and outcome of psychosis
This study extends the findings of short-term follow-up studies by confirming an association between duration of untreated psychosis and ‘midterm’ outcome. Expand
Incidence and clinical correlates of aggression and violence at presentation in patients with first episode psychosis
Overall, despite a high rate of verbal aggression, physical violence towards other people is uncommon in individuals presenting with first episode psychosis. Expand