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Eutrophication causes speciation reversal in whitefish adaptive radiations
Evidence is provided that species diversity evolved in response to ecological opportunity, and that eutrophication, by diminishing this opportunity, has driven extinctions through speciation reversal and demographic decline, and it is argued that extinction by Speciation reversal may be more widespread than currently appreciated. Expand
The phylogeographic importance of the Strait of Gibraltar as a gene flow barrier in terrestrial arthropods: a case study with the scorpion Buthus occitanus as model organism.
The phylogenetic relationship between Buthus occitanus populations across the Strait of Gibraltar was investigated using nuclear 18S/ITS-1 DNA sequences and mitochondrial 16S and COI DNA sequences.Expand
The city‐fox phenomenon: genetic consequences of a recent colonization of urban habitat
The results indicate that the two urban areas were independently founded by a small number of individuals from adjacent rural areas resulting in genetic drift and genetic differentiation between rural and urban fox populations. Expand
High frequency of multiple paternity in the largest rookery of Mediterranean loggerhead sea turtles
Investigating patterns of multiple paternity in clutches of loggerhead sea turtles in the largest Mediterranean rookery using four highly variable microsatellite loci suggests that polyandry is likely to increase effective population size compared to a population in which females would mate with only one male. Expand
Colonization history of the Swiss Rhine basin by the bullhead (Cottus gobio): inference under a Bayesian spatially explicit framework
The demographic estimates of the European bullhead suggest that the Swiss Rhine basin was colonized very recently, after the Younger Dryas some 6600 years ago. Expand
Assessment of natural and artificial propagation of the white‐clawed crayfish (Austropotamobius pallipes species complex) in the Alpine region with nuclear and mitochondrial markers
The mosaic distribution of the five evolutionary lineages indicated that conservation efforts should be aimed at the level of local populations, and gave additional information about the likelihood of their natural or artificial origin. Expand
Divergence along a steep ecological gradient in lake whitefish (Coregonus sp.)
The first in‐depth investigation of whitefish diversity in a Swiss lake, with continuous spawning habitat sampling in both time and space, shows a clear cline like pattern in genetics and morphology of populations sampled along an ecological depth gradient in Lake Neuchâtel. Expand
Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity.
The current knowledge on well-known and frequently studied DPYD variants such as the c.1905+1G>A splice site variant is reviewed, as well as the recent discoveries of important functional variation in the noncoding regions of DPYD. Expand
Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient
This systematic review and meta-analysis found that DPYD variants c.1679T>G and c.1236G>A/HapB3 are clinically relevant predictors of fluoropyrimidine-associated toxicity, and upfront screening for these variants, in addition to the established variants DPYD*2A andc.2846A>T, is recommended to improve the safety of patients with cancer treated with fluoropyridines. Expand
Recent habitat fragmentation caused by major roads leads to reduction of gene flow and loss of genetic variability in ground beetles
Findings strongly support the hypothesis that large roads are absolute barriers to gene flow in C. violaceus, which may lead to a loss of genetic variability in fragmented populations. Expand