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Dose Mapping After Endoradiotherapy with 177Lu-DOTATATE/DOTATOC by a Single Measurement After 4 Days
- H. Hänscheid, C. Lapa, A. Buck, M. Lassmann, R. Werner
- MedicineThe Journal of Nuclear Medicine
- 1 January 2018
A single quantitative measurement of the abdominal activity concentration by SPECT/CT 4 d after the administration of 177Lu-DOTATATE/DOTatOC provides a 3-dimensional dose map and can be used to estimate the doses actually absorbed in the treatment cycle with minor additional resources and effort.
Biodistribution and Radiation Dosimetry for a Probe Targeting Prostate-Specific Membrane Antigen for Imaging and Therapy
68Ga-PSMA I&T exhibits a favorable dosimetry, delivering organ doses that are comparable to (kidneys) or lower than those delivered by 18F-FDG.
Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy
In contrast to conventional PET parameters, assessment of intratumoral heterogeneity demonstrated superior prognostic performance in pNET patients undergoing PRRT, and might be useful for patient risk stratification.
68Ga-PSMA-PET/CT in Patients With Biochemical Prostate Cancer Recurrence and Negative 18F-Choline-PET/CT
The sequential imaging approach designed to limit 68Ga-PSMA imaging to patients with negative choline scans resulted in high detection rates and increased with higher serum PSA levels and PSA vel.
In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma
It is concluded that [68Ga]Pentixafor PET opens a broad field for clinical investigations on CX CR4 expression and for CXCR4‐directed therapeutic approaches in MM and other diseases.
CXCR4 Ligands: The Next Big Hit?
- A. Walenkamp, C. Lapa, K. Herrmann, H. Wester
- Biology, ChemistryThe Journal of Nuclear Medicine
- 1 September 2017
Molecular imaging with recently developed radiolabeled CX CR4 ligands could facilitate the selection of patients who might benefit from directed targeted therapy, including CXCR4-directed endoradiotherapy, with some of them reaching clinical trials.
68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors
A stronger association of increased 68Ga-DOTATATE uptake with known risk factors of cardiovascular disease as compared to 18F-FDG is found, suggesting a potential role for plaque imaging in large arteries.
Detection of cardiac amyloidosis with 18F-Florbetaben-PET/CT in comparison to echocardiography, cardiac MRI and DPD-scintigraphy
- M. Kircher, Sandra Ihne, C. Lapa
- Medicine, BiologyEuropean Journal of Nuclear Medicine and…
- 23 February 2019
Imaging of cardiac amyloidosis (CA) with 18F-florbetaben-PET/CT is feasible and might be useful in differentiating CA subtypes, as assessed by cardiac biomarkers and performance status.
Intraoperative 3-D imaging improves sentinel lymph node biopsy in oral cancer
- C. Bluemel, K. Herrmann, U. Müller-Richter
- MedicineEuropean Journal of Nuclear Medicine and…
- 31 July 2014
FhSPECT is a feasible technology that allows the accurate identification of SLNs in oral cancer and overcomes the shine-through phenomenon, one of the most important limitations ofSLNB, thereby confirming the importance of SLNB in patients with cN0 oral cancer.
18F-FDG PET Detects Inflammatory Infiltrates in Spinal Cord Experimental Autoimmune Encephalomyelitis Lesions
Spinal cord inflammatory lesions in the EAE model can be noninvasively visualized in vivo using MRI and 18F-FDG PET/CT, and neither 18-FET nor 18-FLT seems to be a suitable marker for the in vivo detection of inflammatory lesions.