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CYFIP/Sra-1 Controls Neuronal Connectivity in Drosophila and Links the Rac1 GTPase Pathway to the Fragile X Protein
- A. Schenck, B. Bardoni, C. Langmann, N. Harden, J. Mandel, A. Giangrande
- Medicine, BiologyNeuron
- 19 June 2003
CYFIP, the fly ortholog of vertebrate FMRP interactors CYFIP1 and CyFIP2, is specifically expressed in the nervous system, providing a bridge between signal-dependent cytoskeleton remodeling and translation.
Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila.
Evidence is presented that Drac1 and Crumbs, a determinant of epithelial polarity, are involved in setting up an actomyosin contractile apparatus that drives amnioserosa morphogenesis by inducing apical cell constriction.
The RING‐finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila
It is reported thatPOSH controls Imd‐mediated immunity signalling in Drosophila and it is shown that POSH binds to and degrades TAK1, a crucial activator of both the JNK and the Relish signalling pathways.
The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development
- E. Verheyen, Ivana Mirkovic, S. Maclean, C. Langmann, Bryan C Andrews, C. MacKinnon
- Biology, MedicineMechanisms of Development
- 1 March 2001
Drosophila nemo was first identified as a gene required for tissue polarity during ommatidial development. We have extended the analysis of nemo and found that it participates in multiple…
Drosophila RhoGAP68F is a putative GTPase activating protein for RhoA participating in gastrulation
- Justina Sanny, Vincent Chui, C. Langmann, Carla Pereira, Baharak Zahedi, N. Harden
- Biology, MedicineDevelopment Genes and Evolution
- 12 April 2006
It is proposed that RhoGAP68F functions as a regulator of RhoA signaling during gastrulation of the embryo, a morphogenetic event driven by cell constriction that involves RHoA signaling.
When do the aminotransferases rise after acute acetaminophen overdose?
The data suggest that risk prediction instruments may be improved by incorporating both the serum AT concentration at initiation of antidotal therapy and its rate of change, as judged by the effects on clotting.
Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose
- M. Sivilotti, T. Green, C. Langmann, M. Yarema, D. Juurlink, D. Johnson
- MedicineClinical toxicology
- 1 October 2010
The APAP × AT multiplication product, calculated at the time of presentation and after several h of antidotal therapy, holds promise as a new risk predictor following APAP overdose.
Canadian Firearms Legislation and Effects on Homicide 1974 to 2008
- C. Langmann
- Political Science, MedicineJournal of interpersonal violence
- 10 February 2012
This study failed to demonstrate a beneficial association between legislation and firearm homicide rates between 1974 and 2008.
Effect of firearms legislation on suicide and homicide in Canada from 1981 to 2016
- C. Langmann
- MedicinePloS one
- 18 June 2020
Canada implemented a series of laws regulating firearms including background and psychological screening, licensing, and training in the years 1991, 1994, and 2001 which had no associated beneficial effect on overall suicide and homicide rates.
Brief to Standing Committee on Public Safety and National Security Re: Bill C-71 an Act to Amend Certain Acts and Regulations in Relation to Firearms
- C. Langmann
- 26 April 2018
Executive Summary: • Background checks increased beyond 5 years will not result in decreased homicide or suicide by firearm and should not be performed. As well questions involving past suicide,…