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Inhibition of food intake in obese subjects by peptide YY3-36.
BACKGROUND The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces foodExpand
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Critical role for peptide YY in protein-mediated satiation and body-weight regulation.
Dietary protein enhances satiety and promotes weight loss, but the mechanisms by which appetite is affected remain unclear. We investigated the role of gut hormones, key regulators of ingestiveExpand
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Attenuated peptide YY release in obese subjects is associated with reduced satiety.
The responses of the gut hormone peptide YY (PYY) to food were investigated in 20 normal-weight and 20 obese humans in response to six test meals of varying calorie content. Human volunteers had aExpand
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Gut Hormones as Mediators of Appetite and Weight Loss After Roux-en-Y Gastric Bypass
Objective:To evaluate the physiologic importance of the satiety gut hormones. Background:Controversy surrounds the physiologic role of gut hormones in the control of appetite. Bariatric surgeryExpand
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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Summary Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated theExpand
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A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.
BACKGROUND Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone. Liraglutide, a glucagon-like peptide-1Expand
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Oxyntomodulin suppresses appetite and reduces food intake in humans.
Oxyntomodulin (OXM) is released from the gut postprandially, in proportion to energy intake, and circulating levels of OXM are elevated in several conditions associated with anorexia. CentralExpand
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Pancreatic polypeptide reduces appetite and food intake in humans.
Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to ingestion of food. Plasma PP has been shown to be reduced in conditions associated with increased food intakeExpand
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Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion
BACKGROUND AND PURPOSE The glucagon‐like peptides GLP‐1 and GLP‐2 are secreted from enteroendocrine L‐cells following nutrient ingestion. Drugs that increase activity of the GLP‐1 axis are highlyExpand
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Remission of Type 2 Diabetes After Gastric Bypass and Banding: Mechanisms and 2 Year Outcomes
Objective: To investigate the rate of type 2 diabetes remission after gastric bypass and banding and establish the mechanism leading to remission of type 2 diabetes after bariatric surgery. SummaryExpand
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