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Organizational effects of early gonadal secretions on sexual differentiation in spatial memory.
TLDR
The data suggest that early exposure to gonadal steroids (probably estradiol) improves acquisition of spatial tasks by reorganizing and simplifying associational-perceptual processes that guide spatial ability. Expand
Corticotropin-releasing factor directly mediates colonic responses to stress.
TLDR
Data suggest that endogenous CRF may mediate stress-induced changes in colonic function, and the actions of exogenous CRF mimicked the effects of stress on the motor activity of the gastrointestinal tract. Expand
Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both.
TLDR
The data demonstrate that perinatal choline supplementation causes long-term facilitative effects on working and reference memory components of a 12-arm radial maze task, and alternations of muscarinic receptor density as indexed by [3H]quinuclidinyl benzilate (QNB) binding and choline acetyltransferase (ChAT) levels in the hippocampus and frontal cortex of adult rats. Expand
Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.
TLDR
Results reveal that alterations in the availability of dietary choline during discrete periods of development lead to changes in hippocampal electrophysiology that last well into adulthood and point to the importance of choline intake during pregnancy for development of brain and memory function. Expand
Choline supplementation during prenatal development reduces proactive interference in spatial memory.
TLDR
The data suggest that the behavioral consequences of early dietary availability of choline may involve the modification of the discriminative abilities used to attend to stimuli that demarcate the end of one trial and the start of another as well as the capacity for remembering the locations that have been visited during a trial. Expand
Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory
TLDR
The results indicated that perinatal choline supplementation increased rats' sensitivity to the 20 s temporal criterion during baseline training and facilitated the clock speed enhancing effects of nicotine during drug testing. Expand
Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats
TLDR
It is indicated that prenatal choline supplementation facilitates cognitive function across the lifespan, whereas prenatal Choline deficiency impairs divided attention and accelerates age-related declines in temporal processing. Expand
Glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdala
TLDR
Evidence that memory storage is modulated by glucocorticoid binding to GRs in noradrenergic cell bodies in the NTS is provided and it is suggested that these modulatory effects are conveyed by ascending projections to the BLA. Expand
Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats.
TLDR
Observations indicate that prenatal dietary manipulation of the amino acid, choline, leads to subsequent significant alterations of LTP induction threshold in adult animals. Expand
Perinatal choline supplementation increases the threshold for chunking in spatial memory
TLDR
Results indicate a higher threshold for implementing a chunking strategy in rats treated perinatally with choline supplementation, possibly due to a cholineinduced increase in memory capacity. Expand
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