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Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs.
Thyrotropin-releasing hormone (TRH), a hypothalamic orally active neuropeptide, has been manifested in a wide range of biological responses. Besides its central role in regulating theExpand
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Novel thyrotropin-releasing hormone analogs: a patent review
Introduction: The potential therapeutic applications of thyrotropin-releasing hormone (TRH) have attracted attention, based on its broad-spectrum neuropharmacological action rather than its endocrineExpand
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Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.
The present study, in general, is aimed to uncover the properties of the transport mechanism or mechanisms responsible for the uptake of NP-647 into Caco-2 cells and, in particular, to understandExpand
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Protective effects of l-pGlu-(2-propyl)-l-His-l-ProNH2, a newer thyrotropin releasing hormone analog in in vitro and in vivo models of cerebral ischemia
In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- andExpand
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Atorvastatin calcium.
Publisher Summary Atorvastatin calcium is used as an adjunct to diet to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels,Expand
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Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice.
TRH-like peptides were synthesized in which the critical N-terminus residue L-pGlu was replaced with various heteroaromatic rings, and the central residue histidine with 1-alkyl-L-histidines. AllExpand
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Synthesis, Receptor Binding, and CNS Pharmacological Studies of New Thyrotropin‐Releasing Hormone (TRH) Analogues
As part of our search for selective and CNS‐active thyrotropin‐releasing hormone (TRH) analogues, we synthesized a set of 44 new analogues in which His and pGlu residues were modified or replaced.Expand
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Facile synthesis of N‐α‐boc‐1,2‐dialkyl‐l‐histidines: Utility in the synthesis of thyrotropin‐releasing hormone (trh) analogs and evaluation of the cns activity
A facile synthesis of N-α-Boc-1,2-dialkyl-L-histidines starting from N-α-trifluoroacetyl-L-histidine methyl ester is reported. The key steps involve direct and regiospecific N-1(τ) ring-alkylation ofExpand
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Chapter 4 fexofenadine hydrochloride.
Publisher Summary This chapter describes fexofenadine hydrochloride (FEX), its nomenclature, formulae, methods of preparation, physical properties, and methods of analysis, stability, drugExpand
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NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G
Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant strains and the failure of BCG vaccine to impart protection. There is anExpand
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