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Prospective study of liver dysfunction in pregnancy in Southwest Wales.
BACKGROUND Liver dysfunction in pregnancy has serious consequences. Its frequency and characteristics have not been systematically documented in Britain. We have prospectively determined incidence,Expand
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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wideExpand
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A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy
OBJECTIVES:Intrahepatic cholestasis of pregnancy (ICP) has a complex etiology with a significant genetic component. Heterozygous mutations of canalicular transporters occur in a subset of ICP casesExpand
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Celiac Disease and Autoimmune Thyroid Disease
Celiac disease (CD) or gluten sensitive enteropathy is relatively common in western populations with prevalence around 1%. With the recent availability of sensitive and specific serological testing,Expand
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Prospective screening for coeliac disease in patients with Graves’ hyperthyroidism using anti‐gliadin and tissue transglutaminase antibodies
Introduction  Coeliac disease (CD) is associated with autoimmune thyroid disease (AITD) although its prevalence among those with Graves’ hyperthyroidism in the UK is unknown. We determined theExpand
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Cost and Impact on Patient Length of Stay of Rapid Molecular Testing for Clostridium difficile
IntroductionA study was performed to assess the cost of a rapid molecular assay (PCR) for diagnosis of Clostridium difficile infection (CDI) and the impact of its routine use on patient length ofExpand
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Real-time polymerase chain reaction correlates well with clinical diagnosis of Clostridium difficile infection.
AIM To determine the clinical utility of a rapid molecular assay for Clostridium difficile infection (CDI) in an acute hospital setting. METHODS From March to September 2011, stool specimens fromExpand
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Scoring systems and risk assessment for upper gastrointestinal bleeding
 Mortality associated with acute upper GI bleeding remains high, expecially among older patients with co-morbid disease. Some deaths are unavoidable but others can be prevented by rapid triage ofExpand
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Prospective study of liver dysfunction in pregnancy in Southwest Wales
Background: Liver dysfunction in pregnancy has serious consequences. Its frequency and characteristics have not been systematically documented in Britain. We have prospectively determined incidence,Expand
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A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life
Background. Irritable bowel syndrome (IBS) is a chronic, difficult to treat condition. The efficacy of Aloe vera in treating IBS symptoms is not yet proven. The purpose of this study was to determineExpand
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