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Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 gene
Hyphal growth in the opportunistic fungal pathogen Candida albicans is believed to contribute to the virulence of the organism by promoting penetration of fungal cells into host tissue. In thisExpand
Candida albicans Biofilms Produce Antifungal-Tolerant Persister Cells
ABSTRACT Fungal pathogens form biofilms that are highly recalcitrant to antimicrobial therapy. The expression of multidrug resistance pumps in young biofilms has been linked to increased resistanceExpand
A contact-activated kinase signals Candida albicans invasive growth and biofilm development.
  • C. Kumamoto
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 12 April 2005
For mammalian cells, contact-dependent regulatory controls are crucially important for controlling cellular proliferation and preventing diseases such as cancer. Candida albicans, an opportunisticExpand
Contributions of hyphae and hypha‐co‐regulated genes to Candida albicans virulence
The fascinating ability of Candida albicans to undergo dramatic changes in cellular morphology has invited speculation that this plasticity in form contributes to the virulence of the organism.Expand
Evidence for specificity at an early step in protein export in Escherichia coli.
We previously described mutations in a gene, secB, which have pleiotropic effects on protein export in Escherichia coli. In this paper, we report the isolation of mutants in which the activity of theExpand
The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway.
The Escherichia coli cytoplasmic protein thioredoxin 1 can be efficiently exported to the periplasmic space by the signal sequence of the DsbA protein (DsbAss) but not by the signal sequence ofExpand
Candida albicans Commensalism and Pathogenicity Are Intertwined Traits Directed by a Tightly Knit Transcriptional Regulatory Circuit
The identification of regulators, circuits, and target genes employed by the fungus Candida albicans to thrive in disparate niches in a mammalian host reveals interconnection between commensal andExpand
Preprotein transfer to the Escherichia coli translocase requires the co‐operative binding of SecB and the signal sequence to SecA
In Escherichia coli, precursor proteins are targeted to the membrane‐bound translocase by the cytosolic chaperone SecB. SecB binds to the extreme carboxy‐terminus of the SecA ATPase translocaseExpand
Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression.
Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression. We propose that Czf1pExpand
Expression of the Candida albicans Morphogenesis Regulator Gene CZF1 and Its Regulation by Efg1p and Czf1p
ABSTRACT The ability of Candida albicans to transit between different cellular morphologies is believed to be important for virulence. Morphological transitions occur in response to a variety ofExpand