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Inverse-Electron-Demand Diels-Alder Reactions of 2-Pyrones: Bridged Lactones and Beyond.
Inverse-electron-demande Diels-Alder reactions of electron-poor 2-pyrones as electrophilic dienes have been extensively studied in the past fifty years and their applications in total synthesis are discussed in detail.
Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings.
A unified oxidative coupling protocol between indole derivatives and 2,3-dihydroxybenzoic acid, mediated by silver oxide, has been developed to produce the core of bipleiophylline and of its biosynthetic precursor, voacalgine A.
Direct oxidative coupling of N-acetyl indoles and phenols for the synthesis of benzofuroindolines related to phalarine.
An oxidative coupling between phenol and N-acetyl indoles was designed, mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and FeCl3, which allowed the regioselective synthesis of benzofuro[3,2-b]indolines, whose structure is found in the natural product phalarine.
FeCl3-mediated Friedel-Crafts hydroarylation with electrophilic N-acetyl indoles for the synthesis of benzofuroindolines.
This indole umpolung allows straightforward access to the tetracyclic benzofuroindoline motif found in the natural product diazonamide A, which is a potent antitumor agent.
Foldamers containing γ-amino acid residues or their analogues: structural features and applications
This review will cover every peptidomimetic oligomer that contains a γ-amino acid or an analogue and presents a structural feature and includes β-peptides but also hybrid α–γ peptides, β–β peptides and analogues such as oligoureas or aminoxy acids.
Electrochemical Dearomative 2,3-Difunctionalization of Indoles.
The use of electrochemistry is reported to perform a direct oxidative dearomatization of indoles leading to 2,3-dialkoxy or 2, 3-diazido indolines under undivided conditions at a constant current and displays excellent functional group compatibility.
Stereodivergent synthesis of substituted N,O-containing bicyclic compounds by sequential addition of nucleophiles to N-alkoxybicyclolactams.
It would be of great interest to realize the successive addition of two nucleophiles directly onto isoxazololactam 3 ; a high level of stereoselectivity should be induced by the shape of the bicyclic framework.
Bioinspired direct access to benzofuroindolines by oxidative [3 + 2] annulation of phenols and indoles.
The straightforward entry to benzofuroindoline containing natural product-like scaffolds has been achieved by a challenging [3 + 2] oxidative coupling between phenols and indoles. The reaction