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Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and…
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.
Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: 3-Month Data From a Randomized Phase 3 Trial.
Once-Daily Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure in the Randomized Phase 3 MERCURY-2 Study.
Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma
- Cheng-Wen Lin, B. Sherman, C. Kopczynski
- Biology, MedicineJournal of ocular pharmacology and therapeutics…
- 13 June 2017
Netarsudil is a novel ROCK/NET inhibitor with high potency in biochemical and cell-based assays, an ability to produce large and durable IOP reductions in animal models, and favorable pharmacokinetic and ocular tolerability profiles.
Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research
Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes
- Rongfang Wang, Jennifer E. Williamson, C. Kopczynski, J. Serle
- MedicineJournal of glaucoma
- 1 January 2015
A dual mechanism of action, increase in tonographic outflow facility, and decrease of aqueous humor flow rates, accounts for the IOP reduction in normotensive monkey eyes.
Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure.
Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms
- R. Ren, Guorong Li, T. Le, C. Kopczynski, W. Stamer, H. Gong
- Medicine, BiologyInvestigative ophthalmology & visual science
- 1 November 2016
Netarsudil acutely increased C by expansion of the JCT and dilating the ESVs, which led to redistribution of aqueous outflow through a larger area of the IW and ESVs and positively correlated with the percentage change in C.