T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
- E. Smith, S. Sorota, W. Greenlee
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 1 August 2010
Total synthesis of the immunosupressant (-)-pironetin (PA48153C).
- G. E. Keck, C. Knutson, S. Wiles
- ChemistryOrganic Letters
- 14 February 2001
[reaction: see text]. Total synthesis of the immunosuppresant pironetin has been achieved by a synthetic route in which the connections between starting materials and the desired structure are…
Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.
- C. Bennett, D. Burnett, Alessio Veltri
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 15 February 2012
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.
- Stephanie Brumfield, P. Korakas, Cheng Li
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 1 December 2012
A Versatile Preparation of α,β-Unsaturated Lactones from Homoallylic Alcohols
- G. E. Keck, Xiang Li, C. Knutson
- Chemistry
- 16 July 1999
A new method for the synthesis of α,β-unsaturated lactones from β-acetoxy aldehydes by reaction with the lithium enolate of methyl acetate was developed. The reaction is relatively insensitive to…
Total Synthesis of the Immunosuppressant (‐)‐Pironetin (PA48153C).
- G. E. Keck, C. Knutson, S. Wiles
- Chemistry
- 3 July 2001
1,3‐Bis(tributylstannyl)‐2‐methylenepropane
- C. Knutson, Tao Yu
- Chemistry
- 14 March 2008
[97616-73-3] C28H60Sn2 (MW 634.20)
InChI = 1S/C4H6.6C4H9.2Sn/c1-4(2)3;6*1-3-4-2;;/h1-3H2;6*1,3-4H2,2H3;;
InChIKey = DIELKJPCYMLKMU-UHFFFAOYSA-N
(allylating reagent for many…
A versatile preparation of alpha,beta-unsaturated lactones from homoallylic alcohols.
- G. E. Keck, X. Y. Li, C. Knutson
- ChemistryOrganic Letters
- 1999
Experimental evidence regarding the mechanism of this one-pot transformation was obtained and the observations are consistent with a pathway involving an initial aldol condensation with subsequent acyl migration, lactonization, and beta-elimination and not an enolate equilibration-aldol mechanism.