• Publications
  • Influence
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
TLDR
Histological thin sections of the regressing tumor showed that anti-APO-1 was able to induce apoptosis in vivo, suggesting induction of apoptosis as a consequence of a signal mediated through cell surface molecules like APO- 1 may be a useful therapeutic approach in treatment of malignancy. Expand
Activation interferes with the APO-1 pathway in mature human T cells.
TLDR
Activation of resting mature T cells or restimulation of activated T cells may induce a transient resistance to apoptotic signals, and activation signals may interfere with the APO-1 pathway and may prevent elimination ofactivated T cells in the periphery (peripheral selection). Expand
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
TLDR
The APO-1 antigen was expressed upon transfection of APo-1 cDNA into BL60-P7 Burkitt's lymphoma cells and conferred sensitivity towards anti-APO- 1-induced apoptosis to the transfectants. Expand
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
TLDR
The sensitivity of lymphoblastoid cell lines to anti-APO-1-mediated apoptosis may open a new therapeutic approach for the treatment of EBV-induced lymphoproliferative lesions in immunocompromised individuals, because these are composed of cells with a lymphobstonoid phenotype. Expand
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
TLDR
The sensitivity of lymphoblastoid cell lines to anti-APO-1-mediated apoptosis may open a new therapeutic approach for the treatment of EBV- induced lymphoproliferative lesions in immunocompromised individuals, because these are composed of cells with a lymphobstonoid phenotype. Expand
Purification and Molecular Cloning of the APO-1 Cell Surface Antigen , a Member of the Tumor Necrosis Factorperve Growth Factor Receptor Superfamily
The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 was previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignantExpand
Cytocidal effects of Escherichia coli hemolysin on human T lymphocytes
TLDR
Kinetic considerations lead to conclude that DNA degradation may, however, represent an epiphenomenon, and killing of T cells is another means through which E. coli hemolysin could directly impair host defense. Expand
Apoptosis in the Apo-1 system
TLDR
This research attacked the mode of action of E.P.C.H.’s “cell reprograming” by focusing on the “spatially-based” component of the immune response to cancer. Expand
APO-I-mediated apoptosis in normal and malignant lymphocytes.
...
1
2
...