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Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea
Streptococcus pyogenes–induced acute rheumatic fever (ARF) is one of the best examples of postinfectious autoimmunity due to molecular mimicry between host and pathogen. Sydenham chorea is the majorExpand
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Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea
Recent evidence suggests that the pathogenesis of Sydenham's chorea following group A streptococcal infection is due to antibodies which develop due to the infection and infiltrate the brain andExpand
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Antibody-mediated neuronal cell signaling in behavior and movement disorders
Behavioral and movement disorders may have antibody responses where mimicry and signal transduction may lead to neuropsychiatric abnormalities. In our study, antibodies in pediatric autoimmuneExpand
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Tubulin Is a Neuronal Target of Autoantibodies in Sydenham’s Chorea1
Sydenham’s chorea is a CNS disorder and sequela of group A streptococcal infection where deposition of Abs in brain may result in movement and neuropsychiatric abnormalities. We studied human mAbsExpand
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Triple Aim in Canada: developing capacity to lead to better health, care and cost
Abstract Quality problem Many modern health systems strive for ‘Triple Aim’ (TA)—better health for populations, improved experience of care for patients and lower costs of the system, but noteExpand
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Identification of Streptococcal M-Protein Cardiopathogenic Epitopes in Experimental Autoimmune Valvulitis
The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5Expand
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Autoantibodies in Sydenham's Chorea Tubulin Is a Neuronal Target of
Madeleine W. CunninghamChristine A. Kirvan, Carol J. Cox, Susan E. Swedo andhttp://www.jimmunol.org/content/178/11/7412J Immunol€2007; 178:7412-7421;Expand