AmphoraNet: the webserver implementation of the AMPHORA2 metagenomic workflow suite.
- C. Kerepesi, D. Bánky, V. Grolmusz
- BiologyGene
- 10 January 2014
COVID‐19 is an emergent disease of aging
- Didac Santesmasses, J. P. Castro, V. Gladyshev
- MedicineAging Cell
- 1 October 2020
The case fatality rate for COVID‐19 grows exponentially with age in all countries tested, with the doubling time approaching that of all‐cause human mortality, and age and age‐related diseases as its major risk factors.
Prediction and characterization of human ageing-related proteins by using machine learning
- C. Kerepesi, B. Daróczy, Ádám Sturm, T. Vellai, A. Benczúr
- BiologyScientific Reports
- 6 March 2018
This work extracted 21000 protein features from various databases, and using these data as an input to state-of-the-art machine learning methods, found a simple classification model based on only 36 protein features, which quantifies the relevance of a given protein in the regulation or mechanisms of the human ageing process.
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging
- C. Kerepesi, Bohan Zhang, Sang-Goo Lee, Alexandre Trapp, V. Gladyshev
- BiologyScience Advances
- 12 March 2021
This study uncovers a natural rejuvenation event during embryogenesis and suggests that the minimal biological age (ground zero) marks the beginning of organismal aging.
The “Giant Virus Finder” discovers an abundance of giant viruses in the Antarctic dry valleys
- C. Kerepesi, V. Grolmusz
- BiologyArchives of Virology
- 18 March 2015
A bioinformatics work-flow is described that is capable of discovering the likely presence of the genomes of giant viruses in metagenomic shotgun-sequenced datasets, and it is shown that most of these samples contain giant viruses, especially in the Antarctic dry valleys.
Profiling epigenetic age in single cells
- Alexandre Trapp, C. Kerepesi, V. Gladyshev
- BiologybioRxiv
- 15 March 2021
It is shown that individual embryonic stem cells exhibit an age close to zero, that certain stem cells in a tissue show a reduced age compared to their chronological age, and that early embryogenesis is associated with the reduction of epigenetic age of individual cells, the latter supporting a natural rejuvenation event during gastrulation.
The Budapest Reference Connectome Server v2.0
- B. Szalkai, C. Kerepesi, Bálint Varga, V. Grolmusz
- Computer ScienceNeuroscience Letters
- 9 December 2014
COVID-19 is an emergent disease of aging
- Didac Santesmasses, J. P. Castro, V. Gladyshev
- MedicinemedRxiv
- 15 April 2020
The case fatality rate for COVID-19 grows exponentially with age in Italy, Spain, South Korea, and China, with the doubling time approaching that of all-cause human mortality, and the gene expression of ACE2, the SARS-CoV-2 receptor, grows in the lung with age, except for subjects on a ventilator.
Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0
- B. Szalkai, C. Kerepesi, Bálint Varga, V. Grolmusz
- BiologyCognitive Neurodynamics
- 15 February 2016
The construction of the version 3.0 of the server is reported, generating the common edges of the connectome of variously parameterizable subsets of the 1015-vertex connectomes of 477 subjects of the Human Connectome Project’s 500-subject release.
Epigenetic aging of the demographically non-aging naked mole-rat
- C. Kerepesi, Margarita V. Meer, V. Gladyshev
- BiologyNature Communications
- 17 January 2022
The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing…
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