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Evaluation of the teratogenic potential of fresh-brewed coffee and caffeine in the rat.
Dilutions of fresh-brewed coffee, at 12.5, 25, and 50% resulting in caffeine intakes of approximately 9, 19, and 38 mg/kg/day, respectively, were consumed by female rats as their sole beverage for 5Expand
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ALTHOUGH the importance of ciliary activity in removing foreign matter from the respiratory system is well recognized there is little quantitative information on the effects of various environmentalExpand
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Role of the entero-hepatic cycle of indomethacin on its metabolism, distribution in tissues and its excretion by rats, dogs and monkeys.
Abstract Dogs excrete most of an i.v. dose of 14 C-indomethacin unchanged in their feces. Monkeys extensively metabolize the drug to deschlorobenzoylindomethacin and excrete it in urine, and rats,Expand
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Activity of cytosine arabinoside (NSC-63878) in a spectrum of rodent tumors.
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Current status of human safety and environmental aspects of fluorescent whitening agents used in detergents in the United States
Fluorescent whitening agents (FWAs) are incorporated into household detergents at approximately 0.5% dry weight in order to maintain fabric whiteness during laundering. Seven different FWAs areExpand
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Arsine poisoning, mode of action and treatment.
1. "Fat soluble" mono and dithiols have been found to prevent the lysis of erythrocytes by arsine in vitro when they are added five minutes after the cells have been exposed to arsine. 2. CertainExpand
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Relationship of phthalanilide-lipid complexes to uptake and retention of 2-chloro-4',4"-di(2-imidazolin-2-yl)terephthalanilide (NSC 60339) by sensitive and resistant P388 leukemia cells.
P388 lymphocytic leukemia cells that are either sensitive or resistant to 2-chloro-4′,4″-di(2-imidazolin-2-yl)terephthalanilide, NSC 60339, take up an equivalent amount of drug 0.5 hr after a singleExpand
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Cigarette Smoke: Charcoal Filters Reduce Components That Inhibit Growth of Cultured Human Cells
Water-soluble components of total cigarette smoke inhibit cell growth and protein synthesis by the KB line of human cells. The cytotoxic components were in both the gas phase and the particulateExpand
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