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Molecular basis of bacterial resistance to chloramphenicol and florfenicol.
Chloramphenicol (Cm) and its fluorinated derivative florfenicol (Ff) represent highly potent inhibitors of bacterial protein biosynthesis. As a consequence of the use of Cm in human and veterinaryExpand
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Use of antimicrobial agents in veterinary medicine and food animal production.
Antimicrobial resistance is a growing area of concern in both human and veterinary medicine. This review presents an overview of the use of antimicrobial agents in animals for therapeutic,Expand
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Distribution of Florfenicol Resistance Genes fexA and cfr among Chloramphenicol-Resistant Staphylococcus Isolates
ABSTRACT A total of 302 chloramphenicol-resistant Staphylococcus isolates were screened for the presence of the florfenicol/chloramphenicol resistance genes fexA and cfr and their localization onExpand
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The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics
ABSTRACT A novel multidrug resistance phenotype mediated by the Cfr rRNA methyltransferase is observed in Staphylococcus aureus and Escherichia coli. The cfr gene has previously been identified as aExpand
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Identification of a Plasmid-Borne Chloramphenicol-Florfenicol Resistance Gene inStaphylococcus sciuri
ABSTRACT The 16.5-kbp plasmid pSCFS1 from Staphylococcus sciurimediated combined resistance to chloramphenicol and florfenicol. The gene responsible for this resistance property, cfr, was cloned andExpand
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A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.
The gene product of cfr from Staphylococcus sciuri confers resistance to chloramphenicol, florfenicol and clindamycin in Staphylococcus spp. and Escherichia coli. Cfr is not similar to any otherExpand
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Identification of the plasmid-borne quinolone resistance gene qnrS in Salmonella enterica serovar Infantis.
OBJECTIVES A Salmonella enterica serovar Infantis isolate of avian origin was investigated for the presence of the gene qnrS, its transferability and its association with other resistance genes. Expand
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Methicillin-Resistant and -Susceptible Staphylococcus aureus Strains of Clonal Lineages ST398 and ST9 from Swine Carry the Multidrug Resistance Gene cfr
ABSTRACT Methicillin-resistant Staphylococcus aureus clonal lineage ST398 and methicillin-susceptible lineage ST9 strains have their main reservoir in swine but can colonize and cause infections inExpand
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Antimicrobial resistance in pasteurella and mannheimia: epidemiology and genetic basis.
Isolates of the genera Pasteurella and Mannheimia cause a wide variety of diseases of great economic importance in poultry, pigs, cattle and rabbits. Antimicrobial agents represent the most powerfulExpand
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Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and their relationship to human isolates.
OBJECTIVES Methicillin-resistant Staphylococcus aureus (MRSA) isolates from pet animals were characterized and compared with human isolates from clonal complexes most prevalent in Central Europe. Expand
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