• Publications
  • Influence
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes. Expand
Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope.
TLDR
Pharmacology and pharmacokinetics of memantine and other NMDA-receptor antagonists in comparison with currently approved drugs for dementia treatment have been discussed and the focus is on 'glutamate excitotoxicity' and glutamate receptors as drug target. Expand
Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats.
TLDR
Investigation of the influence of chronic administration of donepezil and lercanidipine on cognitive impairment in male Sprague-Dawley rats injected twice with ICV STZ found that the effect of combination of these two drugs on memory and cholinesterase activity was higher than that obtained with either of the drugs when used alone. Expand
Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats#
TLDR
Peroxynitrite decomposition catalysts (FeTMPyP and FeTPPS) produced prominent neuroprotection even if administered 6 h post MCAO and the neuroprotective effect is at least in part due to the reduction of peroxyn itrite and apoptosis. Expand
Determination of rifampicin and its main metabolite in plasma and urine in presence of pyrazinamide and isoniazid by HPLC method.
TLDR
The method developed proved to be suitable for simultaneous estimation of rifampicin and desacetyl rifampsicin in plasma and urine samples and good correlations were obtained between the found and intended values. Expand
Characterization of azithromycin hydrates.
TLDR
Hydrates of azithromycin were characterized and anhydrous AZI was found to be hygroscopic and converted to DH on storing at room temperature and molecular modeling studies revealed the probable sites of attachment of water molecules to AZI. Expand
Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats.
TLDR
It is demonstrated that the adult male rats on a HFD for 4 weeks exhibited the characteristic features of obesity, insulin resistance and glucose intolerance, namely increased body weight, increased total fat pad weight, mild basal/fasting hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia and impaired oral glucose tolerance. Expand
Comparative bioavailability of rifampicin, isoniazid and pyrazinamide from a four drug fixed dose combination with separate formulations at the same dose levels.
TLDR
FDC formulation is bioequivalent for rifampicin, isoniazid and pyrazinamide and ensures the successful treatment of TB without compromising therapeutic efficacy of any of these components of anti-TB therapy. Expand
Effect of tempol on altered angiotensin II and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance.
TLDR
Results indicate that superoxide radicals play crucial role in enhanced contractile and impaired vasodilatory responses to Ang II and ACh, respectively, in thoracic aortic rings isolated from diet-induced insulin resistant rats. Expand
Acute hyperglycemia attenuates nerve conduction velocity and nerve blood flow in male Sprague-Dawley rats: reversal by adenosine.
TLDR
It is concluded that acute hyperglycemia attenuates MNCV and NBF via an adenosinergic receptor-dependent mechanism. Expand
...
1
2
3
4
5
...