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Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative.
This article reports on the development and reliability of the Diagnostic Interview for Genetic Studies (DIGS), a clinical interview especially constructed for the assessment of major mood andExpand
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Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. ToExpand
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Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium.
The Genetics Initiative of the National Institute of Mental Health (NIMH) was a multisite study that created a national repository of DNA from families informative for genetic linkage studies ofExpand
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A multicentre inter-rater reliability study using the OPCRIT computerized diagnostic system.
We examined the reliability of the OPCRIT system from ratings produced by 30 USA and European clinicians involved in molecular genetic research. The OPCRIT system facilitates a polydiagnosticExpand
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Traumatic brain injury and schizophrenia in members of schizophrenia and bipolar disorder pedigrees.
OBJECTIVE Schizophrenia following a traumatic brain injury could be a phenocopy of genetic schizophrenia or the consequence of a gene-environment interaction. Alternatively, traumatic brain injuryExpand
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Odor discrimination deficits in schizophrenia: association with eye movement dysfunction.
Odor discrimination deficits were found in 80% of 20 schizophrenia patients and in none of the 20 age- and sex-matched comparison subjects. Olfactory discrimination was reliably measured in theExpand
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Suicidal behavior in schizophrenia: characteristics of individuals who had and had not attempted suicide.
OBJECTIVE This study compares demographic and clinical characteristics of 52 individuals with schizophrenia or schizoaffective disorder who had attempted suicide with those of 104 individuals withExpand
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Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.
A major challenge in human genetics is identifying the molecular basis of common heritable disorders. In contrast to rare single-gene diseases, multifactorial disorders are thought to arise from theExpand
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Minor Physical Anomalies in Schizophrenia
Using the Waldrop scale, minor physical anomalies were studied in 82 Caucasian subjects, including 41 schizophrenic and 8 bipolar adults, as well as 14 normal and 19 mentally retarded adults. AnExpand
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Diagnostic accuracy and confusability analyses: an application to the Diagnostic Interview for Genetic Studies.
The dominant, contemporary paradigm for developing and refining diagnoses relies heavily on assessing reliability with kappa coefficients and virtually ignores a core component of psychometricExpand
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