• Publications
  • Influence
Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency.
We performed molecular genetic analysis of 24 subjects from 19 families with 17-hydroxylase deficiency in Brazil. Of 7 novel CYP17 mutations, 2 (W406R and R362C) account for 50% and 32% of the mutantExpand
  • 161
  • 7
Cushing's syndrome in pregnancy: an overview.
Cushing's syndrome (CS) during pregnancy is a rare condition with fewer than 150 cases reported in the literature. Adrenal adenomas were found to be the commonest cause, followed by Cushing'sExpand
  • 68
  • 6
  • Open Access
Adrenal masses: characterization with in vivo proton MR spectroscopy--initial experience.
PURPOSE To prospectively determine the accuracy of in vivo proton ((1)H) magnetic resonance (MR) spectroscopy in distinguishing adrenal adenomas, pheochromocytomas, adrenocortical carcinomas, andExpand
  • 61
  • 3
Reassessment of the predictive value of the postural stimulation test in primary aldosteronism.
Postural stimulation tests (PST) from 146 patients with primary aldosteronism were reviewed: 83 had an aldosterone-producing adenoma (APA), 48 idiopathic hyperaldosteronism (IHA), nine primaryExpand
  • 57
  • 3
Disorders of steroid 17 alpha-hydroxylase deficiency.
The human P450c17 alpha gene (CYP17) is a single copy gene located in chromosome 10, consisting of 8 exons and 7 introns. 17 alpha-Hydroxylase/17,20-lyase deficiency is one of two hypertensive formsExpand
  • 44
  • 3
Increased diagnostic probability of subclinical Cushing's syndrome in a population sample of overweight adult patients with type 2 diabetes mellitus.
Endogenous Cushing's Syndrome (CS) is unusual. Patients with subclinical CS (SCS) present altered cortisol dynamics without obvious manifestations. CS occurs in 2-3% of obese poorly controlledExpand
  • 31
  • 3
  • Open Access
Disorders of Steroid 17α-Hydroxylase Deficiency
This article reviews some clinical and biochemical aspects of the 17a-hydroxylase/17,20-lase deficiency. The authors data, obtained from 20 patients that are virtually all hypogonadic females or maleExpand
  • 114
  • 2
Cystic phaeochromocytoma is a distinctive subgroup with special clinical, imaging and histological features that might mislead the diagnosis
To report and analyse cases of cyctic phaeochromocytoma at our institution and in previous publications, as adrenal cystic masses are usually associated with nonfunctional lesions, but they can beExpand
  • 40
  • 2
Neonatal treatment with monosodium glutamate increases plasma corticosterone in the rat.
Monosodium glutamate (MSG) has been shown to alter several neuroendocrine functions in neonatally treated rats. To evaluate for possible alterations in the hypothalamic-pituitary-adrenal axis, weExpand
  • 48
  • 2
One-year clinical evaluation of single morning dose prednisolone therapy for 21-hydroxylase deficiency.
Replacement schedules with hydrocortisone (HC) to treat 21OHD are generally unsatisfactory and partially successful regarding growth. Noncompliance is common since its short half-life requires TIDExpand
  • 34
  • 2
  • Open Access