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BDNF is essential to promote persistence of long-term memory storage
Persistence is a characteristic attribute of long-term memories (LTMs). However, little is known about the molecular mechanisms that mediate this process. We recently showed that persistence of LTMExpand
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BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation
Background The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control of a subset of mRNAs through regulation of its initiation step. In neurons, mTOR is present at theExpand
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mTOR signaling in the hippocampus is necessary for memory formation
It is widely accepted that the formation of long-term memory (LTM) requires mRNA translation, but little is known about the cellular mechanisms in the brain that regulate this process. MammalianExpand
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Delayed wave of c-Fos expression in the dorsal hippocampus involved specifically in persistence of long-term memory storage
Memory formation is a temporally graded process during which transcription and translation steps are required in the first hours after acquisition. Although persistence is a key characteristic ofExpand
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Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc
Many psychiatric disorders, despite their specific characteristics, share deficits in the cognitive domain including executive functions, emotional control and memory. However, memory deficits haveExpand
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Molecular signatures and mechanisms of long-lasting memory consolidation and storage
A body of evidence emerged in the last decade regarding late posttraining memory processing. Most of this new information comes from aversively motivated learning tasks that mainly depend onExpand
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Maintenance of long-term memory storage is dependent on late posttraining Egr-1 expression
Expression of immediate-early genes, like Egr-1, has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is widely thought to play an important role inExpand
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Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures
Although much is known about long-term memory (LTM) consolidation, what puts the “long” in LTM is the exclusive feature of persisting over time. However, until recently the molecular mechanismsExpand
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Medial prefrontal cortex dopamine controls the persistent storage of aversive memories
Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependentExpand
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Requirement of an Early Activation of BDNF/c‐Fos Cascade in the Retrosplenial Cortex for the Persistence of a Long‐Lasting Aversive Memory
Abstract During the past few years, there has been growing interest in the role of the retrosplenial cortex (RSC) in memory processing. However, little is known about the molecular changes that takeExpand
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