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An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4*
TLDR
These findings indicate that TLR activation causes the formation of a highly oligomeric signaling platform analogous to the death-inducing signaling complex of the Fas receptor pathway.
The Severe Acute Respiratory Syndrome Coronavirus Nsp15 Protein Is an Endoribonuclease That Prefers Manganese as a Cofactor
TLDR
A similar endoribonucleolytic activity was detected for the orthologous protein from another coronavirus, demonstrating that the endorIBonuclease activity of Nsp15 may be common to coronaviruses.
Structure of STING bound to c-di-GMP Reveals the Mechanism of Cyclic Dinucleotide Recognition by the Immune System
STING (stimulator of interferon genes) is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons. STING's C-terminal domain forms a V-shaped dimer and
Characterization of a host protein associated with brome mosaic virus RNA-dependent RNA polymerase.
TLDR
Analysis of a host protein associated with the RNA-dependent RNA polymerase (RdRp) from brome mosaic virus (BMV)-infected barley suggests that association with translation factors may be a general feature of RNA replication by (+)-strand RNA viruses.
Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.
TLDR
Whether all RdRps will have structures similar to those found in the poliovirus polymerase structure is addressed and structural predictions are used to explain the phenotypes of a collection of mutations that exist in several RNA polymerases.
The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA*
TLDR
To establish the structural basis of dsRNA recognition by the RLRs, the 2.0-Å resolution crystal structure of human LGP2 C-terminal domain bound to an 8-bp ds RNA is determined.
Effects of Single Nucleotide Polymorphisms on Toll-like Receptor 3 Activity and Expression in Cultured Cells*
TLDR
Molecular modeling suggests that two SNPs, N284I and L412F, could affect the packing of the leucine-rich repeating units in TLR3, which are needed for proper signaling in Toll-like receptor 3.
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