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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsicExpand
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Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.
The live attenuated bacillus Calmette-Guérin (BCG) vaccine for the prevention of disease associated with Mycobacterium tuberculosis was derived from the closely related virulent tubercle bacillus,Expand
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New use of BCG for recombinant vaccines
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. ExtrachromosomalExpand
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A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
Mycobacterium tuberculosis, which causes tuberculosis, is the greatest single infectious cause of mortality worldwide, killing roughly two million people annually. Estimates indicate that one-thirdExpand
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Characterization of a Pseudomonas aeruginosa Efflux Pump Contributing to Aminoglycoside Impermeability
ABSTRACT Pseudomonas aeruginosa can employ many distinct mechanisms of resistance to aminoglycoside antibiotics; however, in cystic fibrosis patients, more than 90% of aminoglycoside-resistantP.Expand
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Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments
The Gram‐positive bacterium Staphylococcus aureus infects diverse tissues and causes a wide spectrum of diseases, suggesting that it possesses a repertoire of distinct molecular mechanisms promotingExpand
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Complete genome sequence of Pseudomonas aeruginosa PAO 1 , an opportunistic pathogen
C. K. Stover*, X. Q. Pham2, A. L. Erwin*, S. D. Mizoguchi*, P. Warrener*, M. J. Hickey*, F.S. L. Brinkman3, W. O. Hufnagle*, D. J. Kowalik*, M. Lagrou*, R. L. Garber*, L. Goltry*, E. Tolentino*, S.Expand
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Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells.
We developed a stringently regulated expression system for mammalian cells that uses (i) the RNA polymerase, phi 10 promoter, and T phi transcriptional terminator of bacteriophage T7; (ii) the lacExpand
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Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria.
To persist in macrophages and in granulomatous caseous lesions, pathogenic mycobacteria must be equipped to withstand the action of toxic oxygen metabolites. In Gram-negative bacteria, the OxyRExpand
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Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine
The current vaccine against tuberculosis, Mycobacterium bovis strain bacille Calmette-Guerin (BCG), offers potential advantages as a live, innately immunogenic vaccine vehicle for the expression andExpand
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