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DARPins: an efficient targeting domain for lentiviral vectors.
We have recently developed a retargeting system for lentiviral vectors (LVs) that relies on the pseudotyping of LVs with engineered measles virus (MV) glycoproteins (hemagglutinin (H) and fusionExpand
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Direct identification of ligand-receptor interactions on living cells and tissues
Many cellular responses are triggered by proteins, drugs or pathogens binding to cell-surface receptors, but it can be challenging to identify which receptors are bound by a given ligand. Here weExpand
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Structural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2.
Human epidermal growth factor receptor-2 (HER2) is a receptor tyrosine kinase directly linked to the growth of malignancies from various origins and a validated target for monoclonal antibodies andExpand
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DARPin-targeting of measles virus: unique bispecificity, effective oncolysis, and enhanced safety.
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent viruses to destroy cancers. Many naturally occurring viruses have a preferential, although nonexclusive,Expand
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Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy
DCs are critical cellular targets of PD-L1 blockade in cancer treatment. Checkpoint musical chairs Anti–PD-1 or PD-L1 antibodies can reinvigorate antitumor immunity in a subset of patients withExpand
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Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs.
Specific binding proteins have become essential for diagnostic and therapeutic applications, and traditionally these have been antibodies. Nowadays an increasing number of alternative scaffolds haveExpand
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TGFβ1 and TGFβ2 mRNA and protein expression in human bone samples
Transforming growth factor beta is one of the most abundant growth factors stored in bone. It is known as a potent regulator of osteoblast proliferation and differentiation as well as of productionExpand
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Analysis of TGFbeta3 gene expression and protein levels in human bone and serum.
Recent data indicate that TGFbeta3, one member of the TGFbeta-isoforms, has an important role in bone remodeling. Up to date little is known about the expression and regulation of TGFbeta3 in man. WeExpand
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Circulating transforming growth factor β1 (TGFβ1) is elevated by extensive exercise
Abstract. Transforming growth factor β1 (TGFβ1) is a multifunctional growth factor involved in immune function, atherosclerosis, fibrotic disease, diabetic complications and bone turnover. It isExpand
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TGFbeta1 and TGFbeta2 mRNA and protein expression in human bone samples.
Transforming growth factor beta is one of the most abundant growth factors stored in bone. It is known as a potent regulator of osteoblast proliferation and differentiation as well as of productionExpand
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