Genome‐wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori
- Eike Niehus, H. Gressmann, C. Josenhans
- BiologyMolecular Microbiology
- 1 May 2004
Flagellar basal body components FlhA and FlhF were characterized as functional equivalents to master regulators in H. pylori, as their absence led to a general reduction of transcripts in the RpoN and FliA regulons, and of 24 genes newly attributed to intermediate regulons.
The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
- S. Suerbaum, C. Josenhans, J. Fox
- Biology, MedicineProceedings of the National Academy of Sciences…
- 16 June 2003
The complete genome sequence of H. hepaticus ATCC51449 is reported, suggesting a role of HHGI1 in pathogenicity and several genomic islets whose G+C content differs from the rest of the genome.
Expression and subcellular distribution of toll‐like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection
- B. Schmausser, M. Andrulis, M. Eck
- BiologyClinical and Experimental Immunology
- 1 June 2004
Polarized and dynamically regulated gastric epithelium expression of TLRs supports a sentinel role for these receptors in the mucosal immunity to H. pylori.
The spatial orientation of Helicobacter pylori in the gastric mucus.
- S. Schreiber, M. Konradt, S. Suerbaum
- BiologyProceedings of the National Academy of Sciences…
- 6 April 2004
To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal perfusion, dialysis, and ventilation were used to modify or invert transmucus gradients in anaesthetized Helicobacter-infected mice and Mongolian gerbils.
The role of motility as a virulence factor in bacteria.
- C. Josenhans, S. Suerbaum
- BiologyInternational Journal of Medical Microbiology
- 2002
This review summarises recent studies that have analysed the role of motility and chemotaxis in the host-parasite relationship of pathogenic bacteria and possibilities to exploit bacterial motility as a specific therapeutic antibacterial target to cure or prevent disease are discussed.
Helicobacter pylori evolution and phenotypic diversification in a changing host
- S. Suerbaum, C. Josenhans
- BiologyNature Reviews Microbiology
- 1 June 2007
It is argued that H. pylori uses mutation and recombination processes to adapt to its individual host by modifying molecules that interact with the host, and put forward the hypothesis that the lack of opportunity for intraspecies recombination as a result of the decreasing prevalence of H.pylori could accelerate its disappearance from Western populations.
Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5.
- Sae-Kyung Lee, A. Stack, Elena Katzowitsch, S. Aizawa, S. Suerbaum, C. Josenhans
- Biology, MedicineMicrobes and infection
- 1 December 2003
The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models
- S. Nell, S. Suerbaum, C. Josenhans
- Medicine, BiologyNature Reviews Microbiology
- 1 August 2010
The impact of pathogenic and commensal bacteria on IBD-like pathogenesis in mouse infection models is focused on and important recent developments are summarized.
Functional characterization of the antagonistic flagellar late regulators FliA and FlgM of Helicobacter pylori and their effects on the H. pylori transcriptome
- C. Josenhans, Eike Niehus, S. Suerbaum
- BiologyMolecular Microbiology
- 1 January 2002
Helicobacter pylori flgM lacks a conserved 20‐amino‐acid N‐terminal domain of enterobacterial FlgM proteins, but was able to interact with the Salmonella typhimuriumσ28 (FliA) and inhibit the expression of FliA‐dependent genes inSalmonella.
Helicobacter pylori genome evolution during human infection
- Lynn Kennemann, X. Didelot, S. Suerbaum
- BiologyProceedings of the National Academy of Sciences
- 7 March 2011
No evidence of recombination and few other differences were identified in the strain pair from an infected volunteer, indicating that the H. pylori genome is stable in the absence of mixed infection and strong in vivo selection for this putative adhesin during early colonization.
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