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Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
IntroductionCytokeratin (CK) 14, one of several markers expressed in normal myoepithelial/basal cells, is also expressed in a proportion of breast carcinomas. Previous studies have suggested that… Expand
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease
- I. Celardo, Ana C. Costa, +6 authors L. M. Martins
- Biology, Medicine
- Cell Death and Disease
- 1 June 2016
Mutations in PINK1 and PARKIN cause early-onset Parkinson’s disease (PD), thought to be due to mitochondrial toxicity. Here, we show that in Drosophila pink1 and parkin mutants, defective… Expand
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
Platelet response to activation varies widely between individuals but shows interindividual consistency and strong heritability. The genetic basis of this variation has not been properly explored. We… Expand
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function.
Mean platelet volume (MPV) and platelet count (PLT) are highly heritable and tightly regulated traits. We performed a genome-wide association study for MPV and identified one SNP, rs342293, as having… Expand
Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
Background— Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or… Expand
Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation
- L. Holbrook, N. A. Watkins, A. D. Simmonds, C. Jones, W. H. Ouwehand, J. Gibbins
- Chemistry, Medicine
- British journal of haematology
- 1 February 2010
The thiol isomerase enzymes protein disulphide isomerase (PDI) and endoplasmic reticulum protein 5 (ERp5) are released by resting and activated platelets. These re‐associate with the cell surface… Expand
Comparative genomic hybridisation analysis of myoepithelial carcinoma of the breast
SUMMARY: Although there seems to be a common stem cell for the two epithelial cell types in the breast, the vast majority of breast cancers exhibit a luminal phenotype. Pure myoepithelial carcinomas… Expand
Beneficial Effects of Clopidogrel Combined With Aspirin in Reducing Cerebral Emboli in Patients Undergoing Carotid Endarterectomy
Background—Postoperative thromboembolic stroke affects 2% to 3% of patients undergoing carotid endarterectomy (CEA) and is preceded by 1 to 2 hours of increasing cerebral embolization. Previous work… Expand
Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.
Within the healthy population, there is substantial, heritable, and interindividual variability in the platelet response. We explored whether a proportion of this variability could be accounted for… Expand
Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus
- C. Jones, S. Garner, +12 authors A. Goodall
- Biology, Medicine
- Journal of thrombosis and haemostasis : JTH
- 1 August 2007
Summary. Background: Evidence suggests the wide variation in platelet response within the population is genetically controlled. Unraveling the complex relationship between sequence variation and… Expand