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Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding*
The γ-aminobutyric acid type B (GABAB) receptor is distantly related to the metabotropic glutamate receptor-like family of G-protein-coupled receptors (family 3). Sequence comparison revealed that,Expand
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1
The main excitatory neurotransmitter in the brain, glutamate (Glu), activates not only receptor-channels, but also receptors coupled to G- protein called metabotropic Glu receptors (mGluRs). EightExpand
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
L-Glutamate (Glu) activates at least eight different G protein-coupled receptors known as metabotropic glutamate (mGlu) receptors, which mostly act as regulators of synaptic transmission. TheseExpand
Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.
The gamma-aminobutyric acid (GABA) receptor type B (GABA(B)R) is constituted of at least two homologous proteins, GABA(B)R1 and GABA(B)R2. These proteins share sequence and structural similarity withExpand
Mapping the Agonist-binding Site of GABAB Type 1 Subunit Sheds Light on the Activation Process of GABABReceptors*
The γ-amino-n-butyric acid type B (GABAB) receptor is composed of two subunits, GABAB1 and GABAB2, belonging to the family 3 heptahelix receptors. These proteins possess two domains, a sevenExpand
The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins (*)
Metabotropic glutamate receptors (mGluR) share no sequence homology with any other G-protein-coupled receptors (GPCRs). The characterization of their G-protein coupling domains will therefore helpExpand
Domains involved in the specificity of G protein activation in phospholipase C‐coupled metabotropic glutamate receptors.
G protein‐coupled glutamate receptors (mGluR) have recently been characterized. These receptors have seven putative transmembrane domains, but display no sequence homology with the large family of GExpand
The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.
The recently identified gamma-aminobutyric acid type B receptors (GABA(B)Rs) share low sequence similarity with the metabotropic glutamate (mGlu) receptors. Like the mGlu receptors, the N-terminalExpand
The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain.
Metabotropic glutamate (mGlu), Ca2+-sensing, gamma-aminobutyric acidB, and a large number of pheromone receptors constitute a peculiar family of G protein-coupled receptors. They possess a largeExpand
The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specificity.
19 Savarese, T. M. and Fraser, C. M. (1 992) Biochem. J. 283, 1-19 Fraser, C. M., Wang, C. D., Robinson, D. A., Gocayne, J. D. and Venter, J. C. (1989) Mol. Pharmacol. 36,840-847 Mansour, A., Meng,Expand
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