C. Johnson

Publications55
h-index24
Citations2,151
Highly Influential Citations62
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Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality.
TLDR
Case-control analysis showed that ineffective erythropoiesis with increasingly severe anemia, hypertension, proteinuria, the nephrotic syndrome, and microscopic hematuria were significant pre-azotemic predictors of chronic renal failure.
The sickle cell hemolytic transfusion reaction syndrome
TLDR
Calculations of daily red cell production and senescence indicated that a marked drop in hematocrit occurs when erythropoiesis is suppressed in a patient with a short red cell life span and that this could account for severe posttransfusion anemia when donor red cells are hemolyzed during an HTR.
Arterial blood pressure in adults with sickle cell disease.
TLDR
Findings in sickle cell disease may be due to the renal tubular defect responsible for increased sodium and water excretion, which may blunt the plasma volume expansion necessary for sustained hypertension and thus promote lower arterial pressures, similar to that situation observed in patients with salt-losing nephritis.
Vascular occlusion in sickle cell disease: current concepts and unanswered questions.
Pregnancy in sickle cell disease.
TLDR
A higher percentage of sickle hemoglobin C disease mothers completed their pregnancies with no complications when compared with sickle cell anemia mothers, thus identifying a subset of women for whom pregnancy does not represent an increased risk.
Diagnosis and Treatment of Patients With Gastroesophageal Reflux and Noncardiac Chest Pain
TLDR
It is concluded that many patients with noncardiac chest pain have gastroesophageal reflux, including those for whom an empiric trial of standard antireflux therapy fails and more aggressive antireFlux therapy often leads to improvement in symptoms.
Liver Involvement in Sickle Cell Disease
TLDR
Some causes of liver disease in sickle cell patients can be explained by clinical disorders other than the hemoglobinopathy alone, including hepatitis, chronic passive congestion, common duct obstruction, alcoholic liver disease, pregnancy, collagen-vascular disease, and sarcoidosis.
Racial patterns in pernicious anemia. Early age at onset and increased frequency of intrinsic-factor antibody in black women.
TLDR
A different form of or a different response to the disease in black women and perhaps in Latin-American women is suggested and may affect others more often than previously thought.
Mechanical properties of oxygenated red blood cells in sickle cell (HbSS) disease.
TLDR
The results show that elevated hemoglobin concentration influences the viscoelastic behavior of ISC and RSC, but that an irreversible change in membrane elasticity also occurs for ISC, suggesting that ISC formation occurs via a two-stage process.
Influence of oxygen tension on the viscoelastic behavior of red blood cells in sickle cell disease.
TLDR
G gross abnormalities in the deformation response of HbSS RBC were only detected after morphological sickling had occurred and most likely arose from changes in the cytoplasmic HbS viscoelasticity and, if present in vivo, would be expected to impair the flow of H bSS cells in the microcirculation.
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