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Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
Of Microbes and Cancer Inflammation is a well-established driver of tumorigenesis. For example, patients with inflammatory bowel disease have an elevated risk of developing colorectal cancer (CRC).Expand
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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components of the inflammasome are protective during acute and recurring colitis and CAC in theExpand
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Toll‐Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
Bacterial lipopolysaccharide (LPS) stimulates Kupffer cells and participates in the pathogenesis of alcohol‐induced liver injury. However, it is unknown whether LPS directly affects hepatic stellateExpand
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Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
NF-kappa B plays a critical role in the transcriptional regulation of proinflammatory gene expression in various cells. Cytokine-mediated activation of NF-kappa B requires activation of variousExpand
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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
Blocking Interfering Microbes Irinotecan is a widely used anticancer pro-drug that is converted in the liver into the active form, but when it gets into the gut, the normally benign microbial floraExpand
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High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse
Background Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as theExpand
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The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection.
  • C. Jobin, R. Sartor
  • Medicine, Biology
  • American journal of physiology. Cell physiology
  • 1 March 2000
The ubiquitous transcription factor NF-kappa B is a central regulator of the transcriptional activation of a number of genes involved in cell adhesion, immune and proinflammatory responses,Expand
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Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility
It is well established that the intestinal microbiota plays a key role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) collectively referred to as inflammatory bowel diseaseExpand
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Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
The function of nuclear factor (NF)-κB within the developing and mature CNS is controversial. We have generated transgenic mice to reveal NF-κB transcriptional activity in vivo. As expected,Expand
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The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
The ubiquitous transcription factor NF-κB is a central regulator of the transcriptional activation of a number of genes involved in cell adhesion, immune and proinflammatory responses, apoptosis, d...
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