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Recurrent Signature Patterns in HIV-1 B Clade Envelope Glycoproteins Associated with either Early or Chronic Infections
Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in infection that may be favored at transmission, as well as patterns of recurrent mutation in chronic infectionExpand
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  • Open Access
Assessment of air quality improvement effect under the National Total Emission Control Program during the Twelfth National Five-Year Plan in China
The National Total Emission Control (NTEC) Program will continue to be implemented during the 12th Five-Year Plan period (FYP, 2011–2015) in China. Two pollutants (SO2 and NOx) are covered by NTEC,Expand
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Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening
Hand, foot and mouth disease (HFMD) is a common pediatric illness mainly caused by infection with enterovirus 71 (EV71) and coxsackievirus A16 (CA16). The frequent HFMD outbreaks have become aExpand
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  • Open Access
Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice
Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) have caused severe epidemics of hand, foot and mouth disease (HFMD) in the Asia Pacific in recent years, particularly in infants and youngExpand
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Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
ABSTRACT The great majority of human immunodeficiency virus type 1 (HIV-1) strains enter CD4+ target cells by interacting with one of two coreceptors, CCR5 or CXCR4. Here we describe aExpand
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DNA and adenovirus tumor vaccine expressing truncated survivin generates specific immune responses and anti-tumor effects in a murine melanoma model
Survivin is overexpressed in major types of cancer and is considered an ideal “universal” tumor-associated antigen that can be targeted by immunotherapeutic vaccines. However, its anti-apoptosisExpand
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Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres.
Exenatide (synthetic exendin-4), a 39-amino acid peptide, was encapsulated in poly(DL-lactic-co-glycolic acid) (PLGA) microspheres as a sustained release delivery system for the therapy of type 2Expand
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Analysis of Cross-Reactive Neutralizing Antibodies in Human HFMD Serum with an EV71 Pseudovirus-Based Assay
Hand, foot and mouth disease, associated with enterovirus 71 (EV71) infections, has recently become an important public health issue throughout the world. Serum neutralizing antibodies are majorExpand
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Preparation and diagnostic use of a novel recombinant single-chain antibody against rabies virus glycoprotein
Rabies virus (RABV) causes a fatal infectious disease, but effective protection may be achieved with the use of rabies immunoglobulin and a rabies vaccine. Virus-neutralizing antibodies (VNA), whichExpand
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Production of influenza H1N1 vaccine from MDCK cells using a novel disposable packed-bed bioreactor
  • Bo Sun, X. Yu, +9 authors C. Jiang
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
  • 1 February 2013
A process for human influenza H1N1 virus vaccine production from Madin–Darby canine kidney (MDCK) cells using a novel packed-bed bioreactor is described in this report. The mini-bioreactor was usedExpand
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