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Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines
Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals. Inflammation resolves spontaneously within a few days,Expand
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Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
Systemic lupus erythematosus (SLE) is a complex disease resulting from inflammatory responses of the immune system against several autoantigens. Inflammation is conditioned by the continuous presenceExpand
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Phospholipids: Key Players in Apoptosis and Immune Regulation
Phosphatidylserine (PS), a phospholipid predominantly found in the inner leaflet of eukaryotic cellular membranes, plays important roles in many biological processes. During apoptosis, the asymmetricExpand
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Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells
Neutrophil extracellular traps (NETs) are fibers of extracellular DNA released from neutrophils due to overwhelming phagocytic stimuli. The function of NETs is to trap and kill microbes to avoidExpand
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Sodium Overload and Water Influx Activate the NALP3 Inflammasome
The NALP3 inflammasome is activated by low intracellular potassium concentrations [K+]i, leading to the secretion of the proinflammatory cytokine IL-1β. However, the mechanism of [K+]i lowering afterExpand
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Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus.
OBJECTIVE Patients with systemic lupus erythematosus (SLE) are often characterized by cellular as well as humoral deficiencies in the recognition and phagocytosis of dead and dying cells. The aim ofExpand
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Redox modulation of HMGB1-related signaling.
SIGNIFICANCE In the cells' nuclei, high-mobility group box protein 1 (HMGB1) is a nonhistone chromatin-binding protein involved in the regulation of transcription. Extracellularly, HMGB1 acts as aExpand
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Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).
Deficiencies in the recognition and phagocytosis of dead and dying cells have been shown to be one of the main alterations in patients with systemic lupus erythematosus (SLE). Cellular as well asExpand
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Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation
Significance The current widespread exposure of humans to natural as well as man-made nanomaterials due to the deployment of nanoparticles (NPs) as food additives, as vaccine- or drug-deliveryExpand
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Navigation to the graveyard-induction of various pathways of necrosis and their classification by flow cytometry.
Apoptosis and necrosis reflect the program of cell death employed by a dying cell and the final stage of death, respectively. Whereas apoptosis is defined as a physiological, highly organized cellExpand
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