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Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines
Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals. Inflammation resolves spontaneously within a few days,… Expand
Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
Systemic lupus erythematosus (SLE) is a complex disease resulting from inflammatory responses of the immune system against several autoantigens. Inflammation is conditioned by the continuous presence… Expand
Phospholipids: Key Players in Apoptosis and Immune Regulation
- R. Chaurio, C. Janko, L. Munoz, B. Frey, M. Herrmann, U. Gaipl
- Chemistry, Medicine
- 30 November 2009
Phosphatidylserine (PS), a phospholipid predominantly found in the inner leaflet of eukaryotic cellular membranes, plays important roles in many biological processes. During apoptosis, the asymmetric… Expand
Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells
- C. Schorn, C. Janko, Melanie Latzko, R. Chaurio, G. Schett, M. Herrmann
- Medicine, Biology
- Front. Immun.
- 4 July 2012
Neutrophil extracellular traps (NETs) are fibers of extracellular DNA released from neutrophils due to overwhelming phagocytic stimuli. The function of NETs is to trap and kill microbes to avoid… Expand
Sodium Overload and Water Influx Activate the NALP3 Inflammasome
- C. Schorn, B. Frey, +9 authors M. Herrmann
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 4 November 2010
The NALP3 inflammasome is activated by low intracellular potassium concentrations [K+]i, leading to the secretion of the proinflammatory cytokine IL-1β. However, the mechanism of [K+]i lowering after… Expand
Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus.
OBJECTIVE Patients with systemic lupus erythematosus (SLE) are often characterized by cellular as well as humoral deficiencies in the recognition and phagocytosis of dead and dying cells. The aim of… Expand
Redox modulation of HMGB1-related signaling.
- C. Janko, M. Filipovic, +4 authors M. Herrmann
- Biology, Medicine
- Antioxidants & redox signaling
- 1 March 2014
SIGNIFICANCE In the cells' nuclei, high-mobility group box protein 1 (HMGB1) is a nonhistone chromatin-binding protein involved in the regulation of transcription. Extracellularly, HMGB1 acts as a… Expand
Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).
Deficiencies in the recognition and phagocytosis of dead and dying cells have been shown to be one of the main alterations in patients with systemic lupus erythematosus (SLE). Cellular as well as… Expand
Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation
- L. Munoz, R. Bilyy, +17 authors M. Herrmann
- Medicine, Materials Science
- Proceedings of the National Academy of Sciences
- 19 September 2016
Significance The current widespread exposure of humans to natural as well as man-made nanomaterials due to the deployment of nanoparticles (NPs) as food additives, as vaccine- or drug-delivery… Expand
Navigation to the graveyard-induction of various pathways of necrosis and their classification by flow cytometry.
Apoptosis and necrosis reflect the program of cell death employed by a dying cell and the final stage of death, respectively. Whereas apoptosis is defined as a physiological, highly organized cell… Expand