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The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.
Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide. Psoriasis is considered to be an autoimmune disease, but the precise nature of the autoantigens triggering T-cellExpand
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BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination.
The function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which includeExpand
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Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides.
OBJECTIVE A distinct subset of proinflammatory CD4+ T cells that produce interleukin-17 was recently identified. These cells are implicated in different autoimmune disease models, such asExpand
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Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
Alteration of the surface glycosylation pattern on malignant cells potentially affects tumor immunity by directly influencing interactions with glycan-binding proteins (lectins) on the surface ofExpand
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Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, inExpand
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Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy.
The immune system must be tightly held in check to avoid bystander tissue damage as well as autoreactivity caused by overwhelming immune reactions. A novel family of immunoregulatory,Expand
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CD127+ innate lymphoid cells are dysregulated in treatment naïve acute myeloid leukemia patients at diagnosis
Innate lymphoid cells (ILCs), defined as lineage negative (Lin−) CD127+ cells, have emerged as novel important immune effector cells, playing a critical role also in tumorExpand
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Recent advances and hurdles in melanoma immunotherapy
Worldwide incidence of malignant melanoma has been constantly increasing during the last years. Surgical excision is effective when primary tumours are thin. At later disease stages patients oftenExpand
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ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence
Non-muscle–invasive bladder cancer (NMIBC) is a highly recurrent tumor despite intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine. In a prospective longitudinalExpand
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Selective accumulation of differentiated FOXP3+ CD4+ T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood
Precise identification of regulatory T cells is crucial in the understanding of their role in human cancers. Here, we analyzed the frequency and phenotype of regulatory T cells (Tregs), in bothExpand
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