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Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics
  • C. Jahr, C. Stevens
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 September 1990
TLDR
The conductance activated in many mammalian CNS neurons by the glutamate analog NMDA is inhibited at hyperpolarized potentials by extracellular magnesium, consistent with the assumption that magnesium inhibits current through the NMDA-activated channel by directly blocking the ion pore. Expand
The time course of glutamate in the synaptic cleft.
TLDR
The time course of free glutamate predicts that dissociation contributes to the decay of the AMPA receptor-mediated postsynaptic current. Expand
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
TLDR
It is reported that stimulation of excitatory axons in the hippocampus elicits inward currents in OPCs that are mediated by AMPA receptors, and electron microscopic analysis revealed that vesicle-filled axon terminals make synaptic junctions with the processes of O PCs in both the young and adult hippocampus. Expand
Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes
TLDR
It is found that stimulation of Schaffer collateral/commissural fibers in hippocampal slices evokes glutamate transporter currents in CA1 astrocytes that activate rapidly, indicating that a significant amount of transmitter escapes the synaptic cleft shortly after release. Expand
Multivesicular Release at Climbing Fiber-Purkinje Cell Synapses
TLDR
This work has estimated the glutamate concentration transient at climbing fiber synapses on Purkinje cells by measuring the inhibition of excitatory postsynaptic currents (EPSCs) produced by a low-affinity competitive antagonist of AMPA receptors, gamma-DGG. Expand
Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale
TLDR
The role of transporters in clearing free glutamate from the synaptic cleft was studied in rat CA1 hippocampal neurons cultured on glial microislands and it was concluded thatTransporters buffer glutamate in the synaptic Cleft. Expand
A quantitative description of NMDA receptor-channel kinetic behavior
  • C. Jahr, C. Stevens
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 June 1990
TLDR
Evaluation of the blocking rates over Mg concentrations from 0.2–200 microM indicate that a single “blocking” mechanism cannot account for the short closed states and that a second voltage-dependent but Mg-independent “blocked” state is necessary to explain the data especially at low M g concentrations. Expand
Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC
TLDR
Deconvolution of the averaged miniature EPSC from the evoked EPSC showed that release probability decays only slightly faster than the EPSC, suggesting that the AMPA receptor EPSC time course is determined primarily by the asynchrony of vesicle release. Expand
NMDA channel behavior depends on agonist affinity
  • R. Lester, C. Jahr
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 February 1992
TLDR
The kinetic properties of NMDA receptor channels activated by exogenous agonists with those activated synaptically are compared and only L-glutamate has an affinity for theNMDA receptor consistent with the time course of the EPSC recorded between hippocampal neurons in culture. Expand
Comparison of Coupled and Uncoupled Currents during Glutamate Uptake by GLT-1 Transporters
TLDR
A kinetic model for GLT-1 was developed to simulate the behavior of both components of the transporter current and to estimate the capture efficiency of GLT -1, predicting that in physiological conditions ∼35% of GLt-1 transporters function as buffers, releasing glutamate back into the extracellular space after binding. Expand
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