C. J. van der Laken

Publications8
h-index6
Citations172
Highly Influential Citations1
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Measurement of O6-ethyldeoxyguanosine and N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene in DNA by high-sensitive enzyme immunoassays.
Antibodies raised in rabbits against the bovine serum albumin conjugates of O6-ethylguanosine and N-(guanosin-8-yl)-N-acetyl-2-aminofluorene have been used to develop a high-sensitive enzyme-linked… Expand
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Immunohistochemical detection of O6-ethyldeoxyguanosine in the rat brain after in vivo applications of N-ethyl-N-nitrosourea.
An immunohistochemical procedure was developed which allows the localization of the DNA lesion O6-ethyldeoxyguanosine (O6-EtdGuo) within tissues and organs. The method permits the detection of 24,000… Expand
  • 31
Immunohistochemical localization of O6-ethyldeoxyguanosine and deoxyguanosin-8-yl-(acetyl)aminofluorene in liver sections of rats treated with diethylnitrosamine, ethylnitrosourea or…
Antibodies raised in rabbits against the bovine serum albumin conjugates of O6-ethylguanosine (O6-EtGuo) and N-(guanosin-8-yl)-N-acetyl-2-aminofluorene (Guo-8-AAF) have been used in a double… Expand
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Modification of deoxyguanosine by chloroethylene oxide.
Reaction of deoxyguanosine in glacial acetic acid with chloroethylene oxide, a proposed reactive metabolite of vinyl chloride, led to a single, strongly fluorescent product in nearly quantitative… Expand
  • 35
Formylmethionyl-tRNA binding to 30 S ribosomes programmed with homopolynucleotides and the effect of translational initiation factor 3.
Binding of the polynucleotides poly(U), poly(X) and poly(dT) to 30 S ribosomes of Escherichia coli triggers IF2-dependent binding of initiator-tRNA (fMet-tRNA) to these particles. Poly(A) and poly(C)… Expand
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Immunological detection and quantification of the reaction products of 2-acetylaminofluorene with guanine in DNA.
Rabbits were immunized with N-(guanosin-8-yl)-N-acetyl-2-aminofluorene bound to bovine serum albumin. The presence of specific antibodies was determined in a radioimmunoassay by competing… Expand
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Function of Escherichia coli ribosomal protein S1 in translation of natural and synthetic messenger RNA.
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Quantitation of carcinogen-DNA adducts by a standardized high-sensitive enzyme immunoassay.
A highly sensitive competitive enzyme immunoassay has been developed, allowing accurate determination of DNA containing the adducts N-(deoxyguanosin-8-yl)-N-acetyl-2-amino-fluorene,… Expand
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