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Determination of isocyanates in air using 1-(2-methoxyphenyl)piperazine-impregnated filters: long-term sampling performance and field comparison with impingers with dibutylamine.
Isocyanates may be harmful to workers and methods for monitoring air exposure in the field are necessary. The main aim of this study was to study the field performance of a method usingExpand
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Upper reference limits for biomarkers of exposure to aromatic diisocyanates
Objectives: The objectives of this study were to determine the levels of 2,4-toluenediamine, 2,6-toluenediamine, 1,5-naphthtalenediamine and 4,4′-methylenediphenyldianiline in hydrolyzed urine andExpand
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Biological monitoring of exposure to 1,5–naphthalene diisocyanate and 4,4’-methylenediphenyl diisocyanate
Objectives: Biological monitoring of occupational sensitizers, such as 1,5-naphthalene diisocyanate (NDI) and 4,4’-methylenediphenyl diisocyanate (MDI) is of high importance. In this study,Expand
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Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate,
Occupational exposure to diisocyanates within the plastic industry causes irritation and disorders in the airway. The aim of this study was to develop, validate and characterize a method for theExpand
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A survey of airborne isocyanate exposure in 13 Swedish polyurethane industries.
Exposure to isocyanates can be harmful to workers by causing different disorders of the airways. The main objectives of this study were to survey the personal 8 h time-weighted average exposure toExpand
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Biological monitoring of exposure to toluene diisocyanate.
OBJECTIVES Toluene diisocyanate (TDI) is used in the manufacture of polyurethane and is a potent inducer of diseases of the airways. In this study, 2,4- and 2,6-toluenediamine in hydrolyzed urine andExpand
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Identification and characterisation of adducts between serum albumin and 4,4’-methylenediphenyl diisocyanate (MDI) in human plasma
Diisocyanates are potent inducers of airways disease. Methylenediphenyl diisocyanate (MDI) is a widely used diisocyanate in the chemical industry. The aim of this study was to identify major and alsoExpand
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Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem
The metabolic conversion of midazolam (MDZ) to its main metabolite 1'-hydroxy-midazolam (1-OH-MDZ) can be used as a probe drug for cytochrome P450 3A (CYP3A) activity. A sensitive method for theExpand
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Anticoagulant counter ion impact on bioanalytical LC-MS/MS assays: results from discussions and experiments within the European Bioanalysis Forum.
BACKGROUND In regulated bioanalysis, the need for partial validation when changing the counter ion of the anticoagulant is currently being debated within the bioanalytical community. To date,Expand
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Determination of the immunomodulator laquinimod in human plasma by liquid chromatography/tandem mass spectrometry; development, validation and application of two methods in clinical pharmacokinetic
Laquinimod (ABR-215062) is a synthetic compound currently undergoing clinical development for oral treatment of multiple sclerosis. The present paper describes the development, validation andExpand
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