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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided. Expand
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
The properties of excipients are discussed, the formulation strategies that can be used for each type of lipid formulation are outlined, and a framework for the in vitro testing of each type is suggested. Expand
Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH.
Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment. Expand
Strategies to Address Low Drug Solubility in Discovery and Development
The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required. Expand
Enhancing intestinal drug solubilisation using lipid-based delivery systems.
The mechanistic rationale which underpins the use of lipid-based delivery systems to enhance drug solubilisation is described and the available literature describing increases in oral bioavailability after the administration of lipid solution, suspension and self-emulsifying formulations is reviewed. Expand
Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility
The fundamental principles that underpin drug precipitation mechanisms are presented, the mechanisms by which precipitation may be inhibited are described, the methods that can be used to identify polymeric precipitation inhibitors (PPIs), and current literature evidence of the most effective PPIs are summarized. Expand
From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control, and the varying mechanisms of lymphatic entry and transport are summarized, as well as discussing examples ofymphatic delivery that have enhanced therapeutic utility. Expand
Lymphatic transport of proteins after subcutaneous administration.
This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration and highlights the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics. Expand
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
Abstract The potential for lipidic self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS) to improve the oral bioavailability of a poorly absorbed,Expand
In vitro assessment of oral lipid based formulations.
The utility of modified dissolution media to predict the impact of food on the absorption of poorly water soluble, lipophilic drugs, is explored and the use of lipid digestion models which have found increasing application in assessment of the interaction of digestible dose forms with the gastrointestinal milieu are contrasted. Expand