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2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics
An estradiol metabolite, 2-methoxyestradiol (2-MeOE(2)), has shown antiproliferative effects in both hormone-dependent and hormone-independent breast cancer cells. Previously, a series ofExpand
Studies toward the total synthesis of the oroidin dimers.
A Diels-Alder/rearrangement sequence is described for the construction of the core ring systems of several oroidin dimers, including ageliferin and palau'amine.
Asymmetric total synthesis of ent-cyclooroidin.
An enantiospecific total synthesis of the pyrrole-imidazole natural product cyclooroidin from histidine is described. The key N1-C9 bond is constructed through an intramolecular SN2-type of reactionExpand
Total Syntheses of Naamidine G and 14-Methoxynaamidine G.
Simple total syntheses of two Leucetta-derived marine alkaloids have been developed using position specific halogen-metal exchange of polyhaloimidazoles to introduce the benzyl substitutedExpand
Total syntheses of kealiinines A-C.
Short total syntheses of the Leucetta-derived alkaloids, kealiinines A-C, have been accomplished using an intramolecular Friedel-Crafts-dehydration sequence of a bis benzylic diol. The precursor diolExpand
An intramolecular azomethine ylide–alkene cycloaddition approach to pyrrolo[3,2-c]quinolines-synthesis of a C2-truncated martinelline model
Abstract The hexahydropyrrolo[3,2-c]quinoline core found in the Martinella alkaloids was constructed through an intramolecular [3+2] azomethine ylide–alkene cycloaddition. Some chemical manipulationsExpand
Enantiomeric Separation of New Chiral Azole Compounds
Twelve new azole compounds were synthesized through an ene reaction involving methylidene heterocycles and phenylmaleimide, producing four oxazoles, five thiazoles, and one pyridine derivative, andExpand
Oxidative rearrangement of imidazoles with dimethyldioxirane.
Tetrahydrobenzimidazoles, on treatment with dimethyldioxirane, rearrange to provide 5-imidazolones exclusively. These rearrangements proceed with a broad range of substrates and with good toExpand
Studies toward the total synthesis of axinellamine and massadine.
Intramolecular Diels-Alder reactions of several N-O linked 4-vinylimidazole dimers provide the expected adduct in moderate to good yield as a single, all trans stereoisomer, along with smallerExpand