• Publications
  • Influence
H-NS: a universal regulator for a dynamic genome
  • C. J. Dorman
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 1 May 2004
The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene expression is overwhelmingly negative and extends throughout the genome, pointing to an almost universal role forExpand
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Bacterial nucleoid-associated proteins, nucleoid structure and gene expression
Emerging models of the bacterial nucleoid show that nucleoid-associated proteins (NAPs) and transcription contribute in combination to the dynamic nature of nucleoid structure. NAPs and otherExpand
  • 601
  • 44
The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium
More than 50 y of research have provided great insight into the physiology, metabolism, and molecular biology of Salmonella enterica serovar Typhimurium (S. Typhimurium), but important gaps in ourExpand
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Anti-silencing: overcoming H-NS-mediated repression of transcription in Gram-negative enteric bacteria.
The H-NS nucleoid-associated DNA-binding protein is an important global repressor of transcription in Gram-negative bacteria. Recently, H-NS has been implicated in the process of xenogeneicExpand
  • 214
  • 21
H-NS, the genome sentinel
  • C. J. Dorman
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 1 February 2007
Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquiredExpand
  • 300
  • 19
A global role for Fis in the transcriptional control of metabolism and type III secretion in Salmonella enterica serovar Typhimurium.
Fis is a key DNA-binding protein involved in nucleoid organization and modulation of many DNA transactions, including transcription in enteric bacteria. The regulon of genes whose expression isExpand
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  • Open Access
A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli
The proU locus encodes an osmotically inducible glycine betaine transport system that is important in the adaptation to osmotic stress. We present evidence that DNA supercoiling plays a key role inExpand
  • 636
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Regulation of gene expression by histone-like proteins in bacteria.
Histone-like proteins in bacteria contribute to the control of gene expression, as well as participating in other DNA transactions such as recombination and DNA replication. They have also beenExpand
  • 237
  • 14
The Shigella virulence gene regulatory cascade: a paradigm of bacterial gene control mechanisms
Shigella flexneri is the causative agent of bacillary dysentery and is a facultative intracellular pathogen. Its virulence regulon is subject to tight control by several mechanisms involving theExpand
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Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo.
The ompC, ompD, and ompF genes encode the three major porins of Salmonella typhimurium. ompR encodes a positive regulator required for the expression of ompC and ompF. Transposon-generated mutationsExpand
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  • Open Access