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Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland
- K. Sleeman, H. Kendrick, D. Robertson, C. Isacke, A. Ashworth, M. Smalley
- Biology, Medicine
- The Journal of cell biology
- 1 January 2007
Flow cytometry is used to prospectively isolate mouse mammary ER-expressing epithelial cells and shown, using analysis of gene expression patterns and cell type–specific markers, that they form a distinct luminal epithelial cell subpopulation that expresses not only the ER but also the progesterone and prolactin receptors. Expand
The mannose receptor family.
The mannose receptor family comprises four glycoproteins each of which is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II (FNII) domain and eight… Expand
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
- K. Sleeman, H. Kendrick, A. Ashworth, C. Isacke, M. Smalley
- Biology, Medicine
- Breast Cancer Research
- 12 December 2005
Differential staining of mammary epithelial cells for CD24 can be used to simultaneously isolate pure populations of non-epithelial, myoepithel/basal and luminal epithelialcells, which is key for understanding mammaries epithelial stem cells in normal tissue biology and carcinogenesis. Expand
Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44
It is demonstrated here that mutations within the ezrin-binding site do not disrupt the plasma membrane localization of CD44 and, in addition, that this region is not required to mediate efficient hyaluronan binding, suggesting that ERM proteins mediate the outside-in, rather than inside-out, signalling of adhesion receptors. Expand
A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer.
GDNF stimulation of RET(+)/GFR alpha 1(+) MCF7 breast cancer cells in vitro enhanced cell proliferation and survival, and promoted cell scattering, indicate that GDNF can act as an important component of the inflammatory response in breast cancers. Expand
A HaemAtlas: characterizing gene expression in differentiated human blood cells
This study represents the most comprehensive analysis of gene expression in hematopoietic cells to date and has identified genes that play key roles in lineage commitment and cell function. Expand
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus
To elucidate the features involved in the conversion of a normal cell-surface receptor gene into an oncogenic one, the complete nucleotide sequence of a human c-fms complementary DNA is determined. Expand
A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion
It is demonstrated for the first time, that fibrillar collagens are extensively deposited in GBMs and that the collagen internalization receptor Endo180 is both highly expressed in these tumors and that it serves to mediate the invasion of tumor cells through collagen-containing matrices. Expand
Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning.
Of novel interest, however, is the high expression of CD44 in regions that do not correlate with sites of known hyaluronan-mediated developmental events, including instructive epithelia participating in epithelial-mesenchymal cell interactions. Expand
Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor.
- D. Wienke, John R MacFadyen, C. Isacke
- Biology, Medicine
- Molecular biology of the cell
- 1 September 2003
It is demonstrated directly using in vitro assays, cell-based studies and tissue immunohistochemistry that Endo180 binds both to native and denatured collagens and evidence that this is mediated by the fibronectin type II domain is provided. Expand