• Publications
  • Influence
SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose andExpand
  • 359
  • 25
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health
Glutamine together with glucose is essential for body's homeostasis. It is the most abundant amino acid and is involved in many biosynthetic, regulatory and energy production processes. SeveralExpand
  • 126
  • 10
Mitochondrial metabolite carrier proteins: purification, reconstitution, and transport studies.
Publisher Summary This chapter also discusses the methods for purifying metabolite carriers from mitochondria, reconstituting them in liposomes, and their transport activities in the reconstitutedExpand
  • 197
  • 9
E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1
ABSTRACT Previous studies have shown that the PDZ-binding motif of the E6 oncoprotein from the mucosal high-risk (HR) human papillomavirus (HPV) types plays a key role in HPV-mediated cellularExpand
  • 47
  • 8
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
Retinoids are micronutrients that are stored as retinyl esters in the retina and hepatic stellate cells (HSCs). HSCs are key players in fibrogenesis in chronic liver diseases. The enzyme responsibleExpand
  • 191
  • 6
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
The carnitine/acylcarnitine carrier (CAC) is a transport protein of the inner mitochondrial membrane that belongs to the mitochondrial carrier protein family. In its cytosolic conformation theExpand
  • 131
  • 5
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
Autism spectrum disorders (ASD) are a group of genetic disorders often overlapping with other neurological conditions. We previously described abnormalities in the branched-chain amino acid (BCAA)Expand
  • 96
  • 4
Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient.
The carnitine-acylcarnitine carrier (CAC) catalyzes the translocation of long-chain fatty acids across the inner mitochondrial membrane. We cloned and sequenced the human CAC cDNA, which has an openExpand
  • 121
  • 3
Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.
The patatin-like phospholipase domain containing 3 (PNPLA3, also called adiponutrin, ADPN) is a membrane-bound protein highly expressed in the liver. The genetic variant I148M (rs738409) was found toExpand
  • 112
  • 3
Purification of reconstitutively active α-oxoglutarate carrier from pig heart mitochondria
The α-oxoglutarate carrier from pig heart mitochondria has been solubilized with Triton X-114 and purified by chromatography on hydroxyapatite and celite in the presence of cardiolipin. When appliedExpand
  • 48
  • 3