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CLASPs Are CLIP-115 and -170 Associating Proteins Involved in the Regional Regulation of Microtubule Dynamics in Motile Fibroblasts
CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the ends of growing microtubules and may act as anti-catastrophe factors. Here, we have isolated twoExpand
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Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control
Cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses can undergo postsynaptically expressed long-term depression (LTD) or long-term potentiation (LTP) depending on whether or not the climbingExpand
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Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex
The small GTPase Rab6a is involved in the regulation of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) in a coat complex coatomer protein I (COPI)-independentExpand
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Deletion of FMR1 in Purkinje Cells Enhances Parallel Fiber LTD, Enlarges Spines, and Attenuates Cerebellar Eyelid Conditioning in Fragile X Syndrome
Absence of functional FMRP causes Fragile X syndrome. Abnormalities in synaptic processes in the cerebral cortex and hippocampus contribute to cognitive deficits in Fragile X patients. So far, theExpand
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A comparison of video and magnetic search coil recordings of mouse eye movements
TLDR
We present the first method for obtaining calibrated video oculography, and contrast the results with simultaneously obtained scleral search coil recordings in C57BL/6 pigmented mice. Expand
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More on climbing fiber signals and their consequence(s)
TLDR
The persistence of many contrasting notions of climbing fiber function after years of investigation testifies that the issue of climbing Fiber contributions to cerebellar transactions is still unresolved. Expand
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The Making of a Complex Spike: Ionic Composition and Plasticity
Abstract: Climbing fiber (CF) activation evokes a large all‐or‐nothing electrical response in Purkinje cells (PCs), the complex spike. It has been suggested that the role of CFs (and thus complexExpand
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Reevaluating the Role of LTD in Cerebellar Motor Learning
Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfereExpand
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Purkinje cells in awake behaving animals operate at the upstate membrane potential
To the Editor: Over the last decades, cellular bistability or multistable states of the membrane potential have been demonstrated both in vitro and in vivo for different types of neurons throughoutExpand
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Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks Cerebellar LTD and Adaptation of the Vestibulo-Ocular Reflex
Cerebellar long-term depression (LTD) is a model system for neuronal information storage that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed to underlieExpand
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