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Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages.
The monoterpene D-limonene and its metabolites have been shown to exert chemopreventive and chemotherapeutic effects against different tumours in animal models and clinical trials. However, it is… Expand
Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts
- E. Yang, Eun-Young Yim, G. Song, Gi-Ok Kim, C. Hyun
- Medicine, Biology
- Interdisciplinary toxicology
- 1 December 2009
Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase… Expand
Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages
Despite its beneficial role in host defense mechanisms, excessive nitric oxide (NO) production by activated macrophages has been implicated in several inflammatory diseases. To clarify the mechanisms… Expand
Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants
To identify new active cosmetics ingredients of natural origin, we screened 299 parts of 263 plant species collected from Jeju Island, the southernmost island of the Korean Peninsula. Plant parts… Expand
Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23.
S-Adenosyl-L-methionine synthetase (SAM-s) catalyzes the biosynthesis of SAM from ATP and L-methionine. Despite extensive research with many organisms, its role in Streptomyces sp. remains unclear.… Expand
An efficient approach for cloning P450 hydroxylase genes from actinomycetes
Oligonucleotide primers were designed and successfully applied to amplify DNA fragments of P450 hydroxylase genes from actinomycetes which produce a large variety of medically important metabolites.… Expand
Oenothera laciniata inhibits lipopolysaccharide induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages.
- W. Yoon, Y. Ham, B. Yoo, J. Moon, J. Koh, C. Hyun
- Biology, Medicine
- Journal of bioscience and bioengineering
- 1 April 2009
We elucidated the pharmacological and biological effects of Oenothera laciniata extracts on the production of inflammatory mediators in macrophages. The CH(2)Cl(2) fraction of O. laciniata extract… Expand
An efficient approach for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer.
- C. Hyun, S. Kim, J. Sohng, J. Hahn, J. Kim, J. Suh
- Biology, Medicine
- FEMS microbiology letters
- 1 February 2000
Specifically designed PCR primers were applied to amplify a segment of dTDP-glucose synthase gene from six actinomycete strains. About 300-bp or 580-bp DNA fragments were obtained from all the… Expand
Compounds with elastase inhibition and free radical scavenging activities from Callistemon lanceolatus
Bioassay-guided investigation of the stems of Callistemon lanceolatus led to the isolation of five compounds such as betulinic acid (1), pyracrenic acid (2), arjunolic acid (3), catechin (4), and… Expand
Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).
Matrix metalloproteinases (MMPs) are the proteases involved in the degradation of the extracellular matrix. MMP-1 is thought to be one of the key enzymes acting in fibrolysis, a process closely… Expand