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Physical Exercise Induces Excess Hsp72 Expression and Delays the Development of Hyperalgesia and Allodynia in Painful Diabetic Neuropathy Rats
TLDR
Progressive exercise training markedly decreases diabetes-associated neuropathic pain, including thermal hyperalgesia and mechanical allodynia, in rats, and this protective effect is related to the increase of Hsp72, but not TNF-&agr; and IL-6, expression in the spinal cord and peripheral nerves of STZ-induced diabetes. Expand
Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation.
TLDR
These results provide new insight regarding the possible molecular mechanisms of quercetin and suppresses oxLDL-induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway. Expand
Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve
TLDR
The results suggest that progressive exercise training decreases peripheral neuropathic pain as well as TNF-&agr; and IL-1&bgr; overproduction and increases HSP72 expression after CCI of the sciatic nerve. Expand
PROGRESSIVE EXERCISE PRECONDITIONING PROTECTS AGAINST CIRCULATORY SHOCK DURING EXPERIMENTAL HEATSTROKE
TLDR
The hypothesis that progressive exercise preconditioning may confer cardiovascular protection during heatstroke by inducing the overexpression of HSP72 in multiple organs is validated and results strongly suggest that HSP 72 preconditionsing with progressive exercise training protects against hyperthermia, circulatory shock, and TNF-α overproduction during heat stroke. Expand
Exercise Combined With Ultrasound Attenuates Neuropathic Pain in Rats Associated With Downregulation of IL-6 and TNF-&agr;, but With Upregulation of IL-10
TLDR
It is found that TU + TE is better than TU or TE alone for treating neuropathic pain and may be straightly associated with less TNF-&agr; and IL-6 expression and more IL-10 expression. Expand
SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through modulation of Toll-like receptor 4.
TLDR
This study demonstrates that exercise intervention improves low back pain symptoms through regulation of the SIRT1 axis with repression of oxidative stress and TLR-4 inhibition. Expand
Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat.
TLDR
Nisoxetine had a local anesthetic effect as infiltrative cutaneous analgesia with durations of actions longer than that of lidocaine or MK-801, suggesting that N-methyl-d-aspartate receptors may not contribute to the cutaneous (local) anestheticeffect of nisxetine or lidocane. Expand
Comparison of hydration, tyrosinase resistance, and antioxidant activation in three kinds of pearl powders.
TLDR
Tests for transepidermal water loss (TEWL) and evaluations of the skin surface hydration of test subjects showed that pearl powder has a satisfactory moisturizing effect on skin and that P-mu has a distinctly stronger moisturizer effect than P-w. Expand
Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis
TLDR
Results showed that administration of Hcy reduced the SIRT1/AMPK/PGC-1α signaling in chondrocytes, leading to mitochondrial dysfunction as a result of increased oxidative stress and apoptosis and revealed insight into the etiology of OA. Expand
Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia.
TLDR
The data indicate a new direction for LOX-1 regulation by the modulation of the PKCβ/NAPDH oxidase/SIRT1/HSF1 mechanism, which might provide a novel route for developing new therapeutic treatments for HHcy. Expand
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