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Structure of C3PO and Mechanism of Human RISC Activation
A Dicer-independent mechanism for human RISC activation is supported, in which Ago2 directly binds duplex siRNA and nicks the passenger strand, and then C3PO activates RISC by degrading the Ago2-nicked passenger strand.
Identification of a candidate therapeutic autophagy-inducing peptide
Through the characterization of a domain of beclin 1 that interacts with HIV-1 Nef, an autophagy-inducing peptide is developed that has potential efficacy in the treatment of human diseases.
Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Comparison of substrate binding and catalytic sites of PanK-III with that of eukaryotic panK-II revealed drastic differences in the binding modes for both ATP and pantothenate substrates, and suggests that these differences may be exploited in the development of new inhibitors specifically targeting PanK -III.
Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820.
Structure and mechanism of a eukaryotic FMN adenylyltransferase.
Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
The "super mutant" of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition.
A structure-based mutagenesis and steady-state kinetic analysis of yeast FMNAT unexpectedly revealed that mutant D181A had a much faster turnover rate than the wild-type enzyme, suggesting that product release may be the rate-limiting step of the reaction.
Crystal Structure of Candida glabrata FMN Adenylyltransferase in complex with FAD and Inorganic Pyrophosphate
Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate and ADP