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Inflammation, a Key Event in Cancer Development
Several recent studies have identified nuclear factor-κB as a key modulator in driving inflammation to cancers. Besides this transcription factor, essential in regulating inflammation and cancerExpand
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Molecular mechanisms of arsenic carcinogenesis
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanismsExpand
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Translocation of Protein Kinase Cε and Protein Kinase Cδ to Membrane Is Required for Ultraviolet B-induced Activation of Mitogen-activated Protein Kinases and Apoptosis*
UV-induced signal transduction may be involved in tumor promotion and induction of apoptosis. The role of protein kinase C (PKC) in UVB-induced signal transduction is not well understood. This studyExpand
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Carcinogenic effect of nickel compounds
Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated epidemiological evidence confirms that exposures to nickel compounds are associated with increased nasalExpand
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RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility*
Background: RhoGDI affects biological activities of small Rho GTPases, leading to regulation of actin polymerization and cell motility. Results: RhoGDI SUMOylation at Lys-138 was crucial for theExpand
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Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts.
Freeze-dried black raspberries have been shown to inhibit the development of chemically induced esophageal and colon cancer in rodents. In addition, organic extracts of black raspberries inhibitExpand
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Vanadium‐induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species
Pulmonary exposure to metals and metal‐containing compounds is associated with pulmonary inflammation, cell death, and tissue injury. The present study uses a mouse model to investigateExpand
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Molecular Mechanisms Involved in Chemoprevention of Black Raspberry Extracts: From Transcription Factors to Their Target Genes
Abstract: Berries have attracted attention for their chemopreventive activities in last a few years. Dietary freeze-dried blackberries have been shown to reduce esophagus and colon cancer developmentExpand
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Estimating viability of plant protoplasts using double and single staining
SummaryThe utility of numerous dyes for determining the viability of barley (Hordeum vulgare L. cv. Himalaya) aleurone protoplasts was studied. Protoplasts isolated from the barley aleurone layerExpand
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Nickel carcinogenesis: epigenetics and hypoxia signaling.
Both water soluble and insoluble nickel compounds have been implicated in the etiology of human lung and nasal cancers. Water insoluble nickel compounds have been shown to enter cells by phagocytosisExpand
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