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Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans.
- C. Huang, C. Xiong, K. Kornfeld
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 25 May 2004
Aging is characterized by progressive, degenerative changes in many tissues. To elucidate the relationships among degenerative changes in Caenorhabditis elegans, we developed methods to measure… Expand
Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial.
BACKGROUND Maintenance treatment of patients with advanced non-small-cell lung cancer (NSCLC) without disease progression after first-line chemotherapy is a subject of ongoing research. The aim of… Expand
Measuring and Evaluating Large-Scale CDNs
CDNs play a critical and central part of today’s Internet infrastructure. In this paper we conduct extensive and thorough measurements that accurately characterize the performance of two large-scale… Expand
Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase 3 study.
BACKGROUND Cisplatin-based adjuvant chemotherapy is the standard of care for patients with resected stage II-IIIA non-small-cell lung cancer (NSCLC). RADIANT and SELECT trial data suggest patients… Expand
On-road vehicle emission inventory and its uncertainty analysis for Shanghai, China.
- Haikun Wang, C. Chen, C. Huang, L. Fu
- Environmental Science, Medicine
- The Science of the total environment
- 15 July 2008
As vehicle population and activity increase, vehicle emissions are becoming the most predominant source of air pollution in Shanghai, China. It has become important to accurately estimate the traffic… Expand
Anlotinib as a third-line therapy in patients with refractory advanced non-small-cell lung cancer: a multicentre, randomised phase II trial (ALTER0302)
Background:Anlotinib (AL3818) is a novel multitarget tyrosine kinase inhibitor, inhibiting tumour angiogenesis and proliferative signalling. The objective of this study was to assess the safety and… Expand
A phase II, multicenter, placebo-controlled trial of apatinib in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after two previous treatment regimens.
7548 Background: Apatinib is an oral, small molecular tyrosine-kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor (VEGFR). Phase II study has showed that apatinib… Expand
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
- Ryuki Hirano, H. Interthal, +14 authors C. Boerkoel
- Biology, Medicine
- The EMBO journal
- 14 November 2007
Tyrosyl‐DNA phosphodiesterase 1 (Tdp1) cleaves the phosphodiester bond between a covalently stalled topoisomerase I (Topo I) and the 3′ end of DNA. Stalling of Topo I at DNA strand breaks is induced… Expand
Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531
Based on the DNA sequences of the junctions between recombinant and cotton genomic DNA of the two genetically modified (GM) cotton varieties, herbicide-tolerance Mon1445 and insect-resistant Mon531,… Expand
Antiviral activities of type I interferons to SARS-CoV-2 infection
- E. Mantlo, N. Bukreyeva, Junki Maruyama, S. Paessler, C. Huang
- Antiviral Research
- 28 April 2020
Abstract There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β).… Expand