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Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence.
BACKGROUND Excessive fluoride exposure is associated with adverse health outcomes, but little is known of the effects of moderately chronic fluoride exposure on children's health. OBJECTIVES WeExpand
Effects of drinking water with high iodine concentration on the intelligence of children in Tianjin, China.
OBJECTIVE This study aimed to investigate the effects of drinking water with high concentrations of iodine on the intelligence of children in Tianjin, China. METHODS It was a population-basedExpand
The role of the IRE1 pathway in excessive iodide- and/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro.
Excessive iodide and fluoride coexist in the groundwater in many regions, causing a potential risk to the human thyroid. To investigate the mechanism of iodide- and fluoride-induced thyroidExpand
Spatial distribution of fluoride in drinking water and health risk assessment of children in typical fluorosis areas in north China.
China has been suffering from endemic fluorosis for the past 30 years. This study investigated fluoride concentrations in 10 districts of Tianjin, China, to illustrate their spatial distributionExpand
Autophagy regulates high concentrations of iodide-induced apoptosis in SH-SY5Y cells.
To date, there are many people residing in areas with high levels of iodide in water. Our previous epidemiological study showed that exposure to high iodine in drinking water significantly reducedExpand
Role of endoplasmic reticulum stress-induced apoptosis in rat thyroid toxicity caused by excess fluoride and/or iodide.
Excess fluoride and iodide coexist in drinking water in many regions, but few studies have investigated the single or interactive effects on thyroid in vivo. In our study, Wistar rats were exposed toExpand
Dopamine receptor D2 gene polymorphism, urine fluoride, and intelligence impairment of children in China: A school-based cross-sectional study.
OBJECTIVE We aimed to study the association of urine fluoride with intelligence quotient (IQ) in children with a careful consideration of up to 30 potential confounding factors as well as possibleExpand
The effects and underlying mechanism of excessive iodide on excessive fluoride-induced thyroid cytotoxicity.
In many regions, excessive fluoride and excessive iodide coexist in groundwater, which may lead to biphasic hazards to human thyroid. To explore fluoride-induced thyroid cytotoxicity and theExpand
[Studies of fluoride on the thyroid cell apoptosis and mechanism].
OBJECTIVE To explore the toxic effect of fluoride on the human thyroid cells (Nthy-ori 3-1) and its mechanism. METHODS Nthy-ori 3-1 cells were exposed to 0.0, 0.1, 1.0, 3.0 mmol/L of sodiumExpand
Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.
In recent years, the detrimental effects of high iodine on intelligence are gaining tons of attention, but the relationship between high iodine and neurotoxicity is controversial. This study aimed toExpand